摘要
目的:探讨冠状动脉左主干病变患者的相关临床特征。方法:分析2006-01至2008-12连续入院并首次行冠状动脉造影的11 956例患者的临床资料,根据冠状动脉造影结果分成两组:左主干病变组(n=693)和非左主干病变组(n=11 263),比较两组患者间的临床特点,包括年龄、性别、糖尿病史、高血压史、吸烟史、高胆固醇血症,以及优势冠状动脉。结果:全部患者平均年龄(55±10)岁,其中9 767例(81.70%)为男性,心肌梗死史5 383例(45.02%),不稳定性心绞痛5 624例(47.04%),合并瓣膜病819例(6.85%)。单因素分析表明左主干病变组年龄、男性患者比例、合并糖尿病史患者均高于非左主干病变组,差异具有显著统计学意义(P值分别为<0.001,<0.001,0.001)。多因素logistic回归分析确定年龄(OR 1.047 95%CI 1.038-1.056;P<0.001)、性别(OR 2.061 95%CI 1.613-2.633;P<0.001)、糖尿病史(OR1.309 95%CI 1.024-1.675;P<0.05)、高胆固醇血症(OR 1.303 95%CI 1.007-1.686;P<0.05)和冠状动脉右优势型(OR0.454 95%CI 0.333-0.620;P<0.001)为左主干病变的独立危险因素。结论:冠状动脉左主干病变为复杂高危病变,年龄、性别、糖尿病史、高胆固醇血症史及优势冠状动脉可能在左主干病变的形成中发挥重要作用。
Objective ：To explore the clinical characteristics in patients with left main coronary artery （LMCA） disease. Methods：We retrospectively analyzed 11 956 consecutive patients who were admitted in our hospital and received the first coronary angiography （CAG） from January 2006 to December 2008. The patients were divided into two groups according to CAG examination as LM group, n = 693 and Non-LM group, n = 11 263. The clinical information as age, gender, history of diabetes, hy- pertension, smoking, hypercholesteremia and dominant coronary artery were studied and compared between two groups. Results：The patients＇ mean age was at （55＋10） years,and 9767 （81.70%） with male gender. There were 5383/11956 （45. 02% ） patients with myocardial infarction,5624 （47.04%） with unstable angina pectoris,819 （6. 85% ） combined with valvular disease. Single factor analysis indicated that the patients in LM group had elder age, more male gender and more history of diabetes than those in Non-LM group,P〈0. 001 respectively. Multivariate logistic regression analysis identified that age （OR 1. 047 95% CI 1. 038 - 1. 056 ,P〈0. 001 ）, gender （ OR 2. 061 95% CI 1. 613 - 2. 633, P〈0. 001 ）, diabetes （ OR 1. 309 95% CI 1. 024 - 1. 675, P〈0. 05 ）, hypereholesteremia （ OR 1. 303 95 % CI 1. 007 - 1. 686, P 〈 0. 05 ） and right dominant coronary artery （ OR 0. 454 95% CI 0. 333 ~ 0. 620 ,P〈0. 001 ） were the independent risk factors for LMCA disease. Conclusion：LMCA was a complicated high risk disease. The age, gender, history of diabetes, hypercholesteremia and dominant coronary artery may play importantroles for LMCA development.
出处
《中国循环杂志》
CSCD
北大核心
2012年第5期338-341,共4页
Chinese Circulation Journal
关键词
左主干病变
冠心病
糖尿病
优势冠状动脉
Left main coronary artery
Coronary artery disease
Diabetes
Dominant coronary artery
