摘要
儿童青少年2型糖尿病发病率日益增高,了解该病的流行现状、危险因素及病理生理学机制十分重要。该病的流行存在明显种族差异性,其危险因素包括肥胖、2型糖尿病家族史、母亲妊娠期高血糖、胎儿宫内发育迟缓及出生体质量异常等,主要通过胰岛素抵抗和胰岛素分泌缺陷这两大病理生理学机制影响血糖。
Type 2 diabetes mellitus in children and adolescents has emerged as a serious public health problem throughout the world. It is important to know more about the epidemiology,risk factors and pathophysiologieal mechanism of this disorder. Extensive studies have found that there is an obvious heterogeneity among different ethnic youth, and the prevalence has been increasing in the world ever since years ago. The risk factors included obesity, family history of diabetes, maternal hyperglycemia in pregnancy, intrauterine growth retardation, abnormal birth weight, and so on. Insulin resistance and beta cell dysfunction are two hallmarks of this disease.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2012年第20期1607-1609,共3页
Journal of Applied Clinical Pediatrics
关键词
2型糖尿病
儿童
青少年
diabetes mellitus, type 2
child
adolescent
