摘要
本文研究了氚标记胸腺嘧啶核苷(8H-TdR)静脉注射后在BALB/C 纯种幼年和成年小白鼠睾丸中的代谢差异及其对成年雄性生殖细胞的损伤效应。注入0.037MBq/g 体重~3H-TdR 后,氚在成年鼠睾丸中的初始负荷量大于幼年鼠,但幼年鼠氚滞留量随时间延长渐渐超过成年鼠。~3H-TdR 可引起成年雄性生殖细胞损伤,表现为显性致死和显性骨骼突变的发生率增高。显性致死的致突变指数Y 与注射~3H-TdR 放射性活度I 的关系为Y=74.13+80.20I;显性骨骼突变发生率B 与注入~3H-TdR 放射性活度I 的关系为B=0.16+7.95×10_(-2)I。
The radiogenetoxicological effects on the adult testis and the metabolic differenceof tritiated thymidine between the testis of young and adult BALB/C mice were stu-died.When 0.037 MBq/g.h.w.of tritiated thymidine was given i.v.to mice,theinitial burden of tritium in the adult was larger than that of tritium in the young.Butthe retention of tritium in testis of the young gradually become larger than that oftritium in the adult with the passing time.Tritiated thymidine which was incorporatedinto DNA of the male germ cell nuclei damaged the genetic materials and caused therising of the rates of the dominant lethal and the dominant mutation which producedskeletal abnomalities in the offspring.The relationship between the dominant lethalmutation index(Y)and the injected activity of tritiated thymidine(Ⅰ,MBq/g.b.w.)isdescribed by Y=74.13+80.20 Ⅰ(r=0.95).The relationship between the incidence ofthe dominant skeletal mutation in the offspring(B)and the injected activity is B=0.16+0.079 Ⅰ(r=0.85).
出处
《苏州医学院学报》
1990年第2期98-101,169-173,共4页
Acta Academiae Medicinae Suzhou
