摘要
目的探讨阿尔茨海默病（Alzheimer diseaseAD）与血管危险因素之间的关系。方法选取临床诊断为AD患者68例作为观察组，认知功能正常老年人70例为对照组。两组性别、职业及受教育程度相匹配，分析两组中高血压、糖尿病、脂代谢紊乱、高同型半胱氨酸血症、颅内各血管血流速度减慢、颈部血管狭窄以及脑梗死的分布情况．以Logistic回归模型分析各因素与AD的关系。结果高血压、糖尿病、血脂代谢异常、高同型半胱氨酸血症、颅内各血管血流速度减慢、颈部血管狭窄以及脑梗死在AD与对照组之间差异有统计学意义（P〈0．05）。结论AD与血管性因素有关，高血压、糖尿病、血脂代谢异常、脑梗死、颈部血管狭窄是AD的独立危险因素。
Objective To investigate the relationship between Alzheimer disease （AD） and arteriosclerosis factors. Methods A case-control study including 68 AD patients and 70 cognitive normal controls was conducted. The patients and controls were matched for gender,occupation and education level. It analyzed the two cases of high blood pressure, diabetes, abnormal lipid metabolism, homocysteine, intimal thickening of the neck, intracranial blood flow slowed dow^p, stroke. The relationship between AD and vascular factors was analyzed by Logistic model. The level of statistical significance of differences in multivariate analysis was P〈0.05. Results Hypertension, diabetes, abnormal lipid metabolism, homocysteine, intimal thickening of the neck vessels, stoke in between the AD and the control group significantly difference （P〈0. 05） . intracranial blood flow slowed down in between AD and control groups were not significantly different （P〉0. 05） . Conclusion AD is associated to vascular factors. High blood pressure, diabetes, abnormal lipid metabolism, homocysteine, intimal thickening of the neck vessels is the independence of the risk of AD factors.
出处
《医学信息》
2012年第9期59-60,共2页
Journal of Medical Information
基金
山西省科技攻关项目,项目编号：20100311109
关键词
阿尔茨海默病
血管因素
认知功能
危险因素
Alzheimer＇s disease
Arteriosclerosis
Cognitive function
Risk factor
