摘要
葡萄糖调节蛋白78(Glucose regulated protein 78ku,GRP78)又称免疫球蛋白重链结合蛋白(Immunoglobulin heavy chain binding protein,Bip),是位于内质网上的一种重要分子伴侣,属热休克蛋白70家族的一员,GRP78分子及其DNA分子序列结构在许多生物物种中高度保守。GRP78在内质网中参与阻止内质网新生肽聚集、调节内质网钙稳态、抗内质网相关性细胞凋亡以及启动未折叠蛋白反应等。近年来发现,GRP78与多种疾病发生发展密切相关,GRP78生物学功能研究已经引起广泛关注。
One of the most important chaperons located on endoplasmic reticulum,GRP78,referred as BiP(Immunoglobulin heavy cha in binding protein),belongs to heat shock protein 70 family.GRP78 exists conservatively among a wide variety of biological species,and acts as a central regulator of endoplasmic reticulum(ER) functions,participating in ER protein folding and assembly process,and maintaining ER Ca2 + homeostasis,un folded protein response and specific anti apoptotic actions.Recently,cellular relationship between GRP78 expression and diseases in human was underwent further clinical and biochemical research,which will benefit to human beings.
出处
《东北农业大学学报》
CAS
CSCD
北大核心
2012年第9期1-5,共5页
Journal of Northeast Agricultural University
基金
国家自然科学基金(31272626)
国家自然科学青年基金(30901088)
关键词
葡萄糖调节蛋白78
研究进展
序列
glucose regulated protein 78 ku
research progress
sequence