摘要
克罗恩病(CD)是一种慢性非特异性肠道炎症性疾病,其发病机制尚未完全明确。近年来随着对肿瘤坏死因子(TNF)-α在CD发病机制中的认识,针对TNF-α的靶向治疗成为关注热点。沙利度胺因具有抑制TNF-α的特性,在CD尤其是难治性CD的治疗中起一定作用。本文就沙利度胺治疗CD的研究进展作一综述。
Crohn's disease (CD) is a chronic non-specific intestinal inflammatory disease and its pathogenesis has not yet been fully clarified. In recent years, with the understanding of involvement of tumor necrosis factor (TNF)-α in the pathogenesis of CD, much attention has been paid on the TNF-α targeted therapy. Thalidomide has anti-TNF-α effect and has been used in the treatment of CD, especially refractory CD. This article reviewed the progress in study on thalidomide for the treatment of CD.
出处
《胃肠病学》
2012年第9期570-572,共3页
Chinese Journal of Gastroenterology