摘要
目的:检测肝癌组织、癌旁组织中酪氨酸蛋白激酶ERK、C-Jun和JAK2的表达,并探讨其临床病理意义。方法:收集武警后勤学院附属医院肝癌手术切除标本60例,采用免疫组化SP法检测ERK、C-Jun和JAK2在肝癌组织、癌旁组织中的表达;采用比例风险模型Cox进行多因素分析,探讨影响肝癌患者预后的因素。结果:肝癌组织中ERK、C-Jun和JAK2平均D值为(0.23±0.03)、(0.18±0.06)、(0.19±0.07),明显高于癌旁组织的[(0.16±0.02),(0.13±0.02),(0.14±0.05,P<0.01];Cox单因素分析显示,C-Jun和JAK2与肝癌患者预后密切相关(P<0.05);Cox多因素分析显示,JAK2是影响肝癌患者预后的重要独立因素。结论:JAK2是影响肝癌患者预后的重要因素,可能作为判断肝癌患者预后的独立指标。
Objective ： To study the clinicopathological significance of the expressions of ERK, C-Jun and JAK2 in hepatic cancer tissues and adjacent tumor tissues. Methods： The expressions of ERK, C-Jun and JAK2 in 60 hepatic cancer specimens and adjacent tumor tissues （from Department of Gastroenterology, Affiliated Hospital of Medical College of Chinese People’s Armed Police Forces） were detected by immunohistochemical SP method. A Cox multivariate analysis was performed in those patients to study the factors that influence the prognosis of hepatic cancer. Results： The average values of ERK, C-Jun and JAK2 in hepatic cancer tissues were significantly higher than that in the tumor-adjacent tissues （／[0.23±0.03／], ／[0.18±0.06／], ／[0.19±0.07／] vs ／[0.16±0.02／], ／[0.13±0.02／], ／[0.14±0.05／], P〈0.01）. The univariate analysis results showed that the major significant prognostic factors influencing survival was the expression of C-Jun and JAK2 （P〈005）, and multivariate analysis revealed that the expression of JAK2 was the most important prognostic factor for hepatic cancer （P〈0.05）. Conclusion： The expression of JAK2 may be an prognostic factor for hepatic cancer patients.
出处
《中国肿瘤生物治疗杂志》
CAS
CSCD
北大核心
2012年第5期531-534,共4页
Chinese Journal of Cancer Biotherapy
基金
武警后勤学院科研启动基金课题(No.WBS200814)~~
