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肝细胞特异性MRI对比剂Gd-EOB-DTPA用于肝细胞功能评估的研究进展 被引量:6

Research progress of liver cell function assessment with hepatocyte-specific MRI contrast agent Gd-EOB-DTPA
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摘要 钆塞酸二钠(Gd-EOB-DTPA)是一种新型肝细胞特异性MRI对比剂,具有缩短T1的作用。功能正常的肝细胞会摄取Gd-EOB-DTPA,而功能受损的肝细胞或非肝细胞来源者则较少甚至不摄取。Gd-EOB-DTPA进入肝细胞主要通过肝细胞膜表面表达的一种名为有机阴离子载体多肽1B3(OATP1B3)实现。因此,可利用Gd-EOB-DTPA能被正常肝细胞摄取这一特性对肝细胞功能进行评价。就利用Gd-EOB-DTPA进行肝细胞MRI检查评价肝细胞功能的研究进展作一综述。
出处 《国际医学放射学杂志》 2012年第5期443-446,共4页 International Journal of Medical Radiology
基金 国家自然科学青年基金项目(81000626) 中央高校基本科研业务费专项资金(10ykpy11) 广东省自然科学基金项目(S2011010004826) 广东省科技计划项目(2010B031600080)
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