摘要
C型利钠肽(C-type natriuretic peptide,CNP)是利钠肽家族成员,主要通过自分泌或旁分泌途径发挥其生物学作用。已有越来越多的研究证实,CNP及其特异性受体利纳肽受体B(natriureticpeptide receptor B,NPR-B)在人类性腺以及胎盘和胚胎组织中高表达,并在精子发生成熟、卵泡发育、早期胚胎发育等多个生殖环节中呈时空特异性表达,提示CNP可能在人类生殖过程中起着重要的调节作用。本文主要对CNP的分子结构、信号转导途径、生物学效应及其在生殖过程中的作用等做一综述。
C-type natriuretic peptide （CNP） belongs to the natriuretic peptide family which mediates its biological effects as a paracrine or autocrine regulator. There is growing evidence that CNP and its specific receptor natriuretic peptide receptor-B （NPR-B） are highly expressed in human gonads, placenta, embryo, and show a spatial and temporal specificity of expression in various reproductive processes during spermatogenesis and mature, follicular development, early embryonic development. These prompt that CNP may play an important role in the regulation of human reproductive processes.This review focuses on the molecular structure, signal transduction, biological effects of CNP and its role in reproductive process.
出处
《生殖与避孕》
CAS
CSCD
2012年第10期694-699,共6页
Reproduction and Contraception
