摘要
目的:观察中药灌肠治疗慢性重型乙型肝炎合并全身炎症反应综合征(SIRS)患者的临床疗效。方法:60例慢性重型乙型肝炎合并全身炎症反应综合征患者随机分为两组,治疗组30例在常规护肝、抗感染等常规治疗的基础上加用中药灌肠,对照组30例仅予护肝、抗感染等常规治疗,两组疗程均为14d;比较两组治疗后有效率、MODS发生率以及病死率及细胞因子、内毒素水平、生化指标等的变化。结果:治疗组有效率达80%,对照组有效率为60%,两组总有效率差异有显著性(P<0.05)。治疗组早期转化为多器官功能障碍综合征者4例,死亡0例,对照组早期转化为MODS者10例,死亡3例,两组比较具有显著性差异(P<0.05),治疗组在疗程结束后细胞因子、内毒素水平、生化指标均有明显改善,其改善程度明显优于对照组(P<0.05)。结论:中药灌肠能明显干预慢性重型乙型肝炎致全身炎症反应,减轻炎症反应,降低内毒素,改善生化指标,明显改善SIRS症状,阻断SIRS向MODS的发展,从而改善慢性重型乙型肝炎的预后。
Purpose Clinical observation of the curative effect of traditional Chinese medicine enema on systemic inflammatory response syn- drome （SIRS） through the treatment of thirty cases of critically ill patients with chronic hepatitis B. Approach Divide stochastically 60 cases of patients suffering from chronic hepatitis B into the two groups of treatment group and control group each with 30 cases. The treatment group receives extra enema therapy in addition to the conventional therapy of liver protection and anti-infection, while the control group on- ly receives the conventional therapy like liver protection and anti-infection. The duration of treatment for the two groups is 14d. A compari- son is to be made of the efficacy rate, MODS incidence as well as the fatality rate, the cell factor, the endotoxin level and the biochemistry indices of the treatment of the two groups. Result Treatment group effectiveness reaches 80%, while control group effectiveness is 60%. The difference between the two groups in terms of treatment validity is conspicuous （P〈0.05）. For the treatment group, there are four cases of MODS at the initial stage and no incidence of death. For the control group, there are ten cases of MODS at the initial stage and three cases of death. Comparison between the two groups is conspicuous （P〈0.05）. The cell factor, the endotoxin level, the biochemistry indices of the treatment group are improved markedly after the end of the treatment, with its improvement degree surpassing the control group obviously （P〈0.05）. Conclusion Traditional Chinese medicine enema can obviously intervene the The Chinese native medicine sausage can intervene the systemic inflammatory response of critically ill patients suffering from chronic hepatitis B, reduce the inflammation reaction, lower the endotoxin, and improve biochemistry indices, relieve the SIRS symptom obviously, block the deterioration of the illness developing from SIRS to the MODS, and thus improve the prognosis of critically ill patients su
出处
《内蒙古中医药》
2012年第17期53-55,共3页
Inner Mongolia Journal of Traditional Chinese Medicine
关键词
全身炎症反应综合征
慢性重型乙型肝炎
中药灌肠
治疗
systemic inflammatory response syndrome
chronic and critical hepatitis B
traditional Chinese medicine enema
treatment
