摘要
目的观察无创正压通气联合纳络酮治疗慢性阻塞性肺疾病（chronicobstructivepulmonarydisease，COPD）合并肺性脑病的临床疗效。方法将86例COPD合并肺性脑病患者随机分为两组，对照组和治疗组，各43例。在常规治疗基础上，对照组给予无创正压通气治疗，治疗组使用无创正压通气联合纳洛酮治疗。结果治疗组在治疗后2h、48hPCO2较治疗前明显改善（P〈0．01），治疗后2h、48hpH、PCO2优于对照组（Pd0．05或P〈0．01）。治疗组气管插管率23％，对照组为42％。结论使用无创正压通气联合纳洛酮治疗COPD肺性脑病患者，较单纯无创正压通气可以更早更有效地改善二氧化碳潴留和pH值，缩短神志恢复时间，降低气管插管率。
Objective To observe the effect of non-invasive positive pressure ventilation （NIPPV） combined with allylnoroxymorphone on chronic obstructive pulmonary disease （COPD） with pulmonary encephalopathy. Methods 86 cases of COPD patients combined with pulmonary encephalopathy were randomly divided into 2 groups, treatment group and control group. On the basis of routine treatment, the control group was treated with NIPPV, while the treatment group was treated with NIPPV combined with allylnoroxymorphone. Results The levels PCO2 was significantly improved at 2 and 48 hours in treatment group compared to those at baseline （ P d0.01）. The level of PCO2 and pH at 2 and 48 hours in treatment group was significantly superior to those in control group （ P d0.05 or P 〈（0.01）. The tracheal intubation rate of the treatment group was 23%, while that of the control group was 42%. Conclusions Compared with NIPPV treatment alone on COPD patients with pulmonary encephalopathy, combined NIPPV and allylnoroxymorphone treatment can improve carbon dioxide retention and the level of pH more earlier and effective, and can shorten the time of consciousness recovered, decrease the tracheal intubation rate.
出处
《国际呼吸杂志》
2012年第18期1399-1401,共3页
International Journal of Respiration
关键词
无创正压通气
纳络酮
慢性阻塞性肺疾病
肺性脑病
Non invasive positive pressure ventilation
Allylnoroxymorphone
Chronic obstructive pulmonary disease
Pulmonary encephalopathy
