摘要
目的探讨中老年男性骨密度(BMD)与脂代谢之间的相关性。方法测定529例中老年男性腰椎(L2～4)和股骨近端(Neck、Troch、Ward’s)BMD及血脂水平,分50～59岁、60～69岁、70～79岁3组,比较3组之间BMD与血脂水平的差异,并作各点BMD与各组血脂的相关分析。结果与50～59岁组比较,60～69岁组及70～79岁组的BMD在L2～4、Neck、Troch、Ward’s区均有降低,差异有统计学意义(P<0.05),与60～69岁组比较,70～79岁组的BMD在L2～4、Neck区有降低,差异有统计学意义(P<0.05);与50～59岁组比较,60～69岁组及70～79岁组的低密度脂蛋白(LDL)、脂蛋白(a)[LP(a)]升高,高密度脂蛋白(HDL)降低,差异有统计学意义(P<0.05),与60～69岁组比较,70～79岁组的LP(a)升高,差异有统计学意义(P<0.05);3组的BMD与LDL负相关(P<0.05),与LP(a)负相关(P<0.05)。结论中老年男性随着年龄增加BMD逐渐下降,并与LDL、LP(a)呈负相关,调脂治疗可能对预防中老年男性骨质疏松症有益。
【Objective】 To explore the relationship between lipid metabolism and bone mineral density（BMD） in middle and senior men.【Methods】 529 middle and senior men were divided into three groups： age stage of 50～59,60～69,70～79.BMD of the lumbar（L2～4） and proximal femur（Neck,Troch,Ward＇s） were measured by dual-energy X-ray.Serum lipid profiles of TG,TC,LDL-ch,HDL-ch,LP（a） were examined.The results were compared among three groups.The relationship between BMD and lipid levels was analyzed with simple linear correlation.【Results】 BMD of L2～4,Neck,Troch and Ward＇s were significantly lower in 60～69 years old group and 70～79 years old group than in 50～59 years old group（P 0.05）.BMD of L2～4 and Neck were significantly lower in 70～79 years old group than in 60～69 years old group（P 0.05）.The levels of LDL and LP（a） were higher in 60～69 years old group and 70～79 years old group than in 50～59 years old group（P 0.05）.The levels of HDL were lower in 60～69 years old group and 70～79 years old group than in 50～59 years old group（P 0.05）.The levels of LP（a） were higher in 70～79 years old group than in 60～69 years old group（P 0.05）.BMD were related negatively to LDL and LP（a） in three groups（P 0.05）.【Conclusion】 In middle and senior men,BMD were decreased with growth of age.BMD were related negatively to LDL and LP（a）.Regulation of lipid levels is beneficial to prevent osteoporosis.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2012年第23期95-98,共4页
China Journal of Modern Medicine
关键词
骨密度
血脂
男性
骨质疏松
bone mineral density
serum lipid
men
osteoporosis
