摘要
WF16616是一种具有抗真菌活性的脂肽类抗生素。以本实验室保藏的菌株SIPI-5553为出发菌株,经过紫外(UV)、亚硝基胍(NTG)等诱变,获得一株高产突变株SIPI-H50,其发酵产物WF16616效价较出发菌株提高约510%。继续优化突变株SIPI-H50的摇瓶发酵工艺,发酵效价为804 mg/L,又提高了86.5%。
A strain named SIPI-5553 kept in our laboratory was used as the starting strain for the fermentation of an antiftmgal lipopeptide, WF 16616. By UV and NTG treatment, one mutant named SIPI-H50 exhibited higher antifungal activity and its productivity of WF16616 was 510% more than that of the original stain. Under the improved fermentation process, the productivity of strain SIPI-H50 was 804 mg/L, an 86.5 % increasement compared with that of the original technology.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2012年第10期817-820,共4页
Chinese Journal of Pharmaceuticals
基金
国家科技重大专项(2010ZX0941-403)
上海市科技人才计划(11XD1423700)
