摘要
目的探讨氯吡格雷联合阿司匹林治疗老年非ST段抬高型急性冠脉综合征(NSTE-ACS)的临床疗效。方法 NSTE-ACS患者58例随机分为治疗组和对照组各29例,对照组应用阿司匹林、低分子肝素等药物治疗及常规治疗,治疗组在对照组治疗基础上口服氯吡格雷,观察比较2组临床疗效及心绞痛发作情况。结果治疗组治愈率和总有效率分别为44.8%和89.7%,高于对照组的27.6%和69.0%,差异有统计学意义(P<0.05)。治疗后2组患者心绞痛发作频率及持续时间均少于治疗前,且治疗组少于对照组,差异均有统计学意义(P<0.05)。结论氯吡格雷联合阿司匹林治疗NSTE-ACS,效果显著,能有效减少心绞痛发作次数及持续时间。
Objective To investigate the clinical efficacy of clopidogrel combined with aspirin in the treatment of elderly patients with non ST-segment elevation acute coronary syndrome （NSTE-ACS）. Methods 58 cases of patients with NSTE -ACS were randomly divided into treatment group and control group, each of 29 cases. The control group was taken with conven- tional treatment according to the disease, plus aspirin and low molecular weight heparin, and the treatment group was treated with oral clopidogrel on the basis of the control group. The clinical efficacy and anginal frequency of 2 groups was taken for ob- servation and comparison. Results The cure rate and total effective rate of the treatment group was 44.8% and 89. 66%, which was better than the control group with the cure rate of 27.6% and total effective rate of 68.97%, and the differences were statistically significant （ P 〈 0.05 ）. After treatment, the angina attack frequency and lasting time of 2 groups were less than before treatment, and on which the treatment group were less than the control group, and the differences were statistically significant （P 〈 0.05 ）. Conclusion Treating NSTE-ACS with clopidogrel combined with aspirin has a significant effect, can effectively reduce the frequency of angina attacks and the daily ischemia time.
出处
《临床合理用药杂志》
2012年第29期7-8,共2页
Chinese Journal of Clinical Rational Drug Use
