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丙型肝炎病毒感染与IL28B多态性遗传关联研究进展 被引量：2

Genetic association of IL28B gene polymorphism with hepatits C virus infection
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摘要 对HCV感染者的全基因组关联研究（genome—wide association studies，GWAS）发现，IL28B单核苷酸多态性（single nucleotide polymorphisms，SNPs）与急性HCV感染的病毒自发清除和抗病毒应答类型密切关联。IL28B多态性结合其他因素可预测HCV感染的转归。IL28B的编码产物干扰素（IFN）-λ3可通过类似于IFN-α的机制上调IFN刺激基因（IFN—stimulated genes，ISGs）的表达。本文综述了IL28B多态性与HCV各基因型之间的关联研究、临床应用及其机制。
作者 何登明 王宇明
机构地区 第三军医大学西南医院感染病科
出处 《中华临床感染病杂志》 CAS 2012年第5期313-317,共5页 Chinese Journal of Clinical Infectious Diseases
关键词 肝炎 丙型 白细胞介素28B 全基因组关联 研究 多态性 单核苷酸 Hepatitis C Interlleukin-28B Genome-wide association study Polymorphism, single nucleotide
分类号 R51 [医药卫生—内科学]
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参考文献36

  • 1Ge D, Fellay J, Thompson AJ, et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature, 2009, 461 (7262) : 399-401. 被引量：1
  • 2Suppiah V, Moldovan M, Ahlenstiel G, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and riba'Jirin therapy. Nat Genet, 2009, 41 (10) : 1100-1104. 被引量：1
  • 3Mangia A, Thompson AJ, Santoro R, et al. An IL28B polymorphism determines treatment response of hepatitis C virus genotype 2 or 3 patients who do not achieve a rapid virologic response. Gastroenterology, 2010, 139 (3) :821-827. 被引量：1
  • 4Sakamoto N, Nakagawa M, Tanaka Y, et al. Association of IL28B variants with response to pegy[ated-interferon alpha plus ribavirin combination therapy reveals intersubgenotypie differences between genotypes 2a and 2b. J Med Yirol, 2011, 83(5) :87|-878. 被引量：1
  • 5Rallon NI, Naggie S, Benito JM, et al. Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. AIDS, 2010, 24 (8) : F23-F29. 被引量：1
  • 6Moghaddam A, Melum E, Reinton N, et al. IL28B genetic variation and treatment response in patients with hepatitis C virus genotype 3 infection. Hepatology, 201 , 53 ( 3 ) : 746-754. 被引量：1
  • 7De Nicola S, Aghemo A, Rumi MG, et al. An IL28B polymorphism predicts pegylated interferon plus ribavirin treatment outcome in chronic hepatitis c genotype 4. Hepatology, 2012, 55 (2) : 336422. 被引量：1
  • 8Asselah T, De Muynck S, Broet P, et al. IL28B polymorphism is associated with treatment response in patients with genotype 4 chronic hepatitis C. J Hepatol, 2012, 56 (3) : 527-532. 被引量：1
  • 9Antaki N, Bibert S, Kebbewar K, et al. IL28B polymorphisms do not predict response to therapy in chronic hepatitis C with I-ICY genotype 5. Gut, 2012. I Epub ahead of printl. 被引量：1
  • 10Thompson AJ, Muir AJ, Sulkowski MS, et al. Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology, 2010,139( 1 ) :120-129. 被引量：1

同被引文献28

  • 1丙型肝炎防治指南[J].临床肝胆病杂志,2004,20(4):197-203. 被引量：735
  • 2World Health Organization. Avilable from: http: //www. who. int/mediacentre/factsheet s/fs164/zh/( 2011 ). 被引量：1
  • 3Ge D, Fellay J, Thompson A J,et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance [ J ]. Na- ture,2009,461 (7262) :399 -401. 被引量：1
  • 4Thomas D L, Thio C L, Martin M P, et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus[ J]. Nature, 2009,461 (7265) :798 - 801. 被引量：1
  • 5Lyoo K, Song M J, Hur W, et al. Polymorphism near the IL28B gene in Korean hepatitis C virus-infected patients treated with peg- interferon plus ribavirin [ J ]. J Clin Viro1,2011,52 ( 4 ) : 363 - 6. 被引量：1
  • 6Ochi H, Maekawa T, Abe H, et al. IL-28B predicts response to chronic hepatitis C therapy-fine-mapping and replication study in Asian populations [ J ]. J Gen Virol, 2011,92 ( 5 ) : 1071 - 81. 被引量：1
  • 7Chen J Y, Lin C Y, Wang C M, et al. IL-28B genetic variations are associated with high sustained virological response (SVR) of interferon-or plus ribavirin therapy in Taiwan Residents chronic HCV in- fection [ J ]. Genes Immun, 2011,12 (4) : 300 - 9. 被引量：1
  • 8Ghany M G, Strader D B, Thomas D L, et al. Diagnosis, man- agement, and treatment of hepatitis C : an update [ J ]. Hepatolo- gy, 2009, 49(4) :1335 -74. 被引量：1
  • 9Rauch A, Kutalik Z, Deseombes P, et al. Genetic variation in IL28B is associated with ehronic hepatitis C and treatment failure: a genome - wide association study [ J ] . Gastroenterology, 2010, 138(4) :1338 -45. 被引量：1
  • 10Imazeki F, Yokosuka O, Omata M. Impact of IL-28B SNPs on control of hepatitis C virus infection: a genome-wide association study [ J ]. Expert Rev Anti Infect Ther, 2010,8 ( 5 ) :497 - 9. 被引量：1

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中华临床感染病杂志
2012年 第5期

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