摘要
血脑屏障的存在使得大部分药物无法进入大脑,从而加大了中枢神经系统疾病的治疗难度。表面修饰的脂质体或一些特殊性质的脂质体可以作为特定的药物载体,将药物运输到相应组织或器官内。该文介绍了近年来脂质体脑靶向制剂,包括经表面修饰的脂质体、热敏脂质体和前阳离子脂质体等的研究进展。
Blood- brain barrier makes the inability of most of the drug to enter the brain, thereby increases the difficulty of central ner- vous system diseases treatment. Surface- modified liposomes and some special properties of liposome could serve as drug carriers to transport drugs to the appropriate tissues or organs. This review summarizes the recent advances of liposomes in brain- targeted drug delivery, including surface- modified liposome,heat- sensitive liposome and procationie liposome.
出处
《中国药业》
CAS
2012年第20期15-17,共3页
China Pharmaceuticals
基金
2011年度安徽省学术与技术带头人科研经费资助项目
项目编号:11040606M193
关键词
脑靶向
血脑屏障
脂质体
brain targeting
blood-brain barrier
liposomes
