摘要
目的:比较TPF、PF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌的近期疗效。方法:70例Ⅱb-Ⅳb期鼻咽癌患者随机分入实验组和对照组,分别行2周期TPF、PF方案诱导化疗,诱导化疗结束后1周开始同期放化疗,期间观察放化疗毒副反应,同期放化疗结束后3个月评价近期疗效。结果:实验组中性粒细胞减少、吞咽困难及脱发较对照组明显增加,实验组CR率为88.5%、PR为11.5%,有效率为100%,对照组CR率为62.9%、PR为34.3%,总有效率97.2%,两组之间近期疗效有统计学差别。结论:TPF方案诱导化疗联合同期放化疗治疗局部晚期鼻咽癌近期疗效优于PF方案诱导化疗联合同期放化疗。
Objective：To investigate the effect of TPF,PF induction chemotherapy followed by cocurrent chemoradiotheapy for local advanced nasopharyngeal carcinoma.Methods： Seventy patients with stageⅡb-Ⅳb nasopharyngeal carcinoma were treated with either experimental group or control group.Two groups were treated by two cycles TPF or PF induction chemotherapy,then accepted cocurrent chemoradiotherapy.The short-term effects were evaluated three months after chemoradiotherapy.Results： The incidence of neutropenia,dysphagia and baldness was significantly increased in experimental group compared with control group.CR,PR were 88.5%and 11.5%respectively in experimental group,the overall response rate was 100%.CR,PR were 62.9% and 34.3% respectively in control group,the overall response rate was 97.2%,there was significant difference between the groups.Conclusion： The TPF induction chemotherapy combined chemoradiotherapy for local advanced nasopharyngeal carcinoma is more effective than PF induction chemotherapy combined chemoradiotherapy in short-term.
出处
《现代肿瘤医学》
CAS
2012年第10期2031-2033,共3页
Journal of Modern Oncology
关键词
鼻咽癌
放射疗法
化学疗法
nasopharyngeal carcinoma
radiotherapy
chemotherapy
