摘要
实验在47只静脉麻醉、肌肉麻痹的家兔上进行。观察到侧脑室注射(icv)SP 20μg引起心输出量、血压明显升高;预先icv心得安100μg或阿托品150μg处理,SP增加心输出量和升压效应仍然存在。提示SP在脑内具有增强心血管活动作用,在其兴奋心血管活动中没有中枢递质乙酰胆碱(Ach)或去甲肾上腺素(NE)的参与。此外,为了解SP与Ach在调节心血管活动的相互关系,本实验还观察到icv毒扁豆碱(PHY)60μg引起心输出量、血压升高;预先icvSP阻断剂25μg可阻断PHY的上述效应,提示Ach调节心血管活动是通过脑内SP起作用的。
Experiments were carried out on 47 anesthetized rabbits which were paralysed with tubocurarine. It was observed that a significant increase in cardiac output(CO)and artery mean blood pressure (MAP)by intracerebroventricular(icv)injection SP 20μg.Preteatment with icv the propranolol 100 μg or atrpine 150μg before 20 min failed to alter the effect of SP.These findings suggest that SP in cerebrum may enhace cardiovascular activity,which does not act via the neural transmitters Ach and NE.In order to investigate that the relationship between SP and Ach in the central control of cardio- vascular functions,we alsoobserved that a increase in CO and MAP during icy physostigmine(PHY) 60μg,and these responses were blocked by pretreatment with icv SP blocker(D-SP)25μg.This sug- gests that Ach controls cardiovascular activity depends of SP.
出处
《遵义医学院学报》
1990年第3期16-20,共5页
Journal of Zunyi Medical University
关键词
P物质
乙酰胆碱
心血管
血压
家兔
substance P(SP)
Ach
NE
cardiac output
blood pressure
icv
rabbits
