摘要
目的 :探讨重组水蛭素对兔髂总动脉球囊损伤后内膜增殖的影响。方法 :2 4只纯种日本大耳白兔随机分成肝素对照组 (n=12 )和重组水蛭素组 (n=12 ) ,采用兔髂总动脉球囊扩张损伤后内膜增殖动物模型 ,术后 2周和 4周复查血管造影 ,术后 4周处死动物取髂总动脉标本。结果 :用药组术后 2周和 4周平均髂总动脉直径均较对照组明显增加 (P<0 .0 1) ,4周后新生内膜面积显著减少 (P<0 .0 1) ,管腔面积明显扩大 (P<0 .0 1)。结论
AIM:To evaluate the effect of recombinant hirudin (r hirudin) in reducing neointimal proliferation after balloon angioplasty in rabbits. METHODS:Twenty four rabbits were randomized into r hirudin group ( n =12) and heparin control group ( n =12),Baloon angioplasty were performed on rabbits normal illiac arterial model. Angiograms were performed at 2 weeks and 4 weeks after procedure. Rabbits were killed 4 weeks after angioplasty. RESULTS:The mean common iliac arterial luminal diameter of r hirudin group was significant increased to compare with heparin control group at 2 weeks ( P <0.01) and 4 weeks ( P <0.01) after balloon angioplasty. At 4 weeks after angioplasty,there were the greater luminal areas ( P <0.01) and the less neointimal areas in r hirudin group ( P <0.01) than in heparin control group. CONCLUSION:r hirudin could significantly lessen neointimal proliferation and luminal stenosis of iliac arteries after balloon angioplasty in rabbits.
出处
《心脏杂志》
CAS
2000年第3期174-176,共3页
Chinese Heart Journal
关键词
血管成形术
重组水蛭素
再狭窄
内膜增殖
balloon angioplasty
recombinant hirudin
restenosis
neointimal proliferation
