摘要
Ritter反应是构筑C-N键的重要手段之一,自1948年被发现以来广泛应用于脂肪族酰胺和杂环化合物(如内酰胺、噁唑啉等)的合成。反应的催化剂也从最初的浓硫酸发展到多种质子酸(如甲磺酸,三氟甲磺酸等)和非质子酸(如SnCl4、BF3OEt2、杂多酸等)。本文综述了Ritter反应的进展及其在有机合成中的应用。
Since the discovery of the Ritter reaction in 1948, it had been widely used for the preparation of acyclic amides as well as heterocycles, such as lactams, oxazolines, etc.. Based on concentrated sulfuric acid, several Bronsted acids （ e. g. methylsulfonic acid, triflic acid, etc. ） as well as Lewis acids （ e. g. SnCl4, BF30Et2, heteropolyacid, etc. ） have been developed to catalyze the reaction. It had been recognized as an important method to build C - N bond. Herein, the advances and main applications of the Ritter reaction were reviewed and summarized.
出处
《山东化工》
CAS
2012年第9期22-27,共6页
Shandong Chemical Industry
