期刊文献+

法舒地尔和地尔硫治疗变异型心绞痛的对比研究 被引量:2

原文传递
导出
摘要 目的观察法舒地尔和地尔硫革对变异型心绞痛患者治疗效果的差异。方法将92例变异型心绞痛患者按机械抽样法随机分为法舒地尔组(30例)、地尔硫革组(31例)和对照组(31例)。对照组接受抗血小板(阿司匹林0.3g/d)、低分子量肝素、13受体阻滞剂、血管紧张素转换酶抑制剂、他汀类降脂药及硝酸酯类药物等基础治疗;法舒地尔组在基础治疗的基础上,给予法舒地尔60mg静脉滴注,每日2次;地尔硫革组在基础治疗的基础上,给予30mg地尔硫革静脉滴注,每日1次;比较入院时、用药1h后的心电图变化,记录患者住院期间心绞痛发作次数,血浆一氧化氮(NO)浓度。结果地尔硫革组与对照组NO浓度比较差异无统计学意义(P〉0.05),法舒地尔组NO浓度明显高于对照组和地尔硫革组[(98.9±17.8)μmol/L比(87.3±8.4)、(89.8±10.8)μmol/L,P〈0.01];三组总ST段降低幅度比较差异无统计学意义(P〉O.05);法舒地尔组住院期间心绞痛发作次数明显低于对照组和地尔硫革组[(1.04±0.97)次比(3.56±2.20)、(1.69±1.27)次,P〈0.01],地尔硫革组住院期间心绞痛发作次数低于对照组(P〈0.05)。结论法舒地尔可以明显改善变异型心绞痛患者的症状,其效果优于地尔硫革。
出处 《中国医师进修杂志》 2012年第28期55-57,共3页 Chinese Journal of Postgraduates of Medicine
基金 内蒙古自治区高等学校科学技术研究项目(NJ09063)
  • 相关文献

参考文献9

  • 1朱成刚,李建军,高立建.单中心192例变异型心绞痛的临床分析[J].中华老年心脑血管病杂志,2009,11(7):502-504. 被引量:4
  • 2Sato M, Tani E, Fujikawa H, et al. Involvement of Rho-kinase- mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res, 2000,87 (3) : 195-200. 被引量:1
  • 3Surma M, Wei L, Shi J. Rho kinase as a therapeutic target in cardiovascular disease. Future Cardiol,2011,7(5) :657-671. 被引量:1
  • 4Otsuka T, Ibuki C, Suzuki T, et al. Administration of the Rho- kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina. Coron Artery Dis, 2008,19(2 ): 105-110. 被引量:1
  • 5蔡建勇,孙军,陈茂华,陆川.盐酸法舒地尔治疗颅内动脉瘤出血后脑血管痉挛的疗效观察[J].中国基层医药,2010,17(10):1367-1368. 被引量:7
  • 6施志杰,钟国富,李峰,王梅.法舒地尔防治蛛网膜下腔出血并发脑血管痉挛临床疗效分析[J].中国基层医药,2010,17(24):3340-3341. 被引量:5
  • 7Satoh K, Fukumoto Y, Shimokawa H. Rho-kinase: important new therapeutic target in cardiovascular diseases. Am J Physiol Heart Circ Physiol, 2011,301(2) :287-296. 被引量:1
  • 8Otsuka T, Ibuki C, Suzuki T,ct al. Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris. Circ J, 2006,70(4) :402-408. 被引量:1
  • 9Inokuchi K, Ito A, Fukumoto Y, et al. The protein kinase inhibitor fasudil protects against ischemic myocardial injury induced by endothelin-1 in the rabbit. J Cardiovasc Pharmacol, 2004,44 (3) : 275-277. 被引量:1

二级参考文献27

  • 1马景鑑,杨树源,魏伟,岳树源,钟跃,杨卫东,张大建,朱士广,朱涛,李萌,杨玉山,李牧,苏炳华,鄂正刚.盐酸法舒地尔治疗蛛网膜下腔出血所致脑血管痉挛的临床Ⅱ期试验研究[J].中华神经外科杂志,2006,22(1):36-40. 被引量:102
  • 2杨林,徐祥麟.颈动脉壁结构变化与心脑血管事件关系的研究[J].中国临床保健杂志,2006,9(3):228-230. 被引量:2
  • 3Sinkiewicz W,Sobanski P,Bartuzi Z.Allergic myocardial infarction.Cardiol J,2008,15:220-225. 被引量:1
  • 4Bertrand ME,LaBlanche JM,Tilmant PY,et al.Frequency of provoked coronary arterial spasm in 1089 consecutive patients undergoing coronary arteriography.Circulation,1982,65:1229-1306. 被引量:1
  • 5Munakata K,Sato N,Sasaki Y,et al.Two cases of variant form angina pectoris associated with myocardial bridge-a possible relationship among coronary vasospasm,atherosclerosis and myocardial bridge.Jpn Circ J,1992,56:1248-1252. 被引量:1
  • 6Tani S,Nagao K,Anazawa T,et al.Treatment of coronary spastic angina with a statin in addition to a calcium channel blocker ; a pilot study.J Cardiovasc Pharmacol,2008,52:28-34. 被引量:1
  • 7Lee J,Cheong SS,Kim J.Association of endothelin-1 gene polymorphisms with variant angina in Korean patients.Clin Chem Lab Med,2008,46:1575-1580. 被引量:1
  • 8Li J J,Zhang YP,Yang P,et al.Increased peripheral circulating inflammatory cells and plasma inflammatory markers in patients with variant angina.Coron Artery Dis,2008,19:293-297. 被引量:1
  • 9Yasue H,Takizawa A,Nagao M,et al.Long-term prognosis for patients with variant angina and influential factors.Criculation,1988,78:1-9. 被引量:1
  • 10Goddard AJP.Raju PPJ.Gholkar A.Does the method of treatment of acutely ruptured intracranial aneurysms influence the incidence and duration of cerebral vasospasm and clinical outcome.Journal of Neurology Neurosurgery and Psychiatry,2004,75 (6):868-872. 被引量:1

共引文献12

同被引文献26

引证文献2

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部