摘要
目的:采用高效液相法建立发用产品中去屑剂吡硫翁锌原料含量测定方法,及吡啶等有关杂质的检查方法。方法:利用乙腈-甲醇(95∶5)混合溶液溶解样品,采用高效液相色谱法测定吡硫翁锌含量,检查吡啶、2-氯代吡啶、2-氨基吡啶、2-羟基吡啶-N氧化物等有关杂质。结果:该含量方法测定吡硫翁锌精密度小于1.0%,加样回收率为98.1%～103.2%。检查各化合物检出限均达到0.6 mg/g。结论:该方法准确、灵敏,适合固体粉末类吡硫翁锌的含量测定和杂质检查,为吡硫翁锌质量控制提供了方法。
Objective：To establish an accurate method for quantitative analysis of antidangdruff agent zinc pyrithione（ZPT）,and a method for impurities test in hair products.Methods： The sample was dissolved with acetonitrile-methanol（95∶ 5）,and then the content of zinc pyrithione in ZPT was determined,and impurities such as pyridine,2-chlorination pyridine,2-aminopyridine and 2-hydroxy pyridine-N oxide were tested by HPLC.Results： The precision was less than 1.0%,and the recoveries were between 98.1%~103.2%.The detection limits of impurities were less than 0.6 mg/g.Conclusion： The methods are accurate,sensitive and suitable for the detemination of ZPT and impurities test in cosmetic material.
出处
《中国卫生检验杂志》
北大核心
2012年第9期2037-2040,共4页
Chinese Journal of Health Laboratory Technology
基金
国家食品药品监督管理局2011年化妆品原料标准制订项目
