摘要
目的探讨淋巴结阴性乳腺癌组织中ATM蛋白的表达,及其与淋巴结阴性乳腺癌临床病理特征和预后之间的关系。方法采用SP免疫组织化学染色方法检测64例淋巴结阴性乳腺癌标本及48例乳腺良性肿瘤组织或正常乳腺组织标本中ATM蛋白的表达。结果 ATM在64例淋巴结阴性乳腺癌组织中的阳性率为53.1%,而在48例乳腺良性肿瘤及正常乳腺组织中的阳性率为72.9%,二者比较差异具有统计学意义(P=0.033)。ATM的表达与患者的HER2受体状态有关(P=0.028),而与患者病理类型、病变部位、年龄、肿块大小、ER状态、PR状态、P53表达状态以及患者总生存率无关。结论 ATM表达降低可能在淋巴结阴性乳腺癌的发生中起到重要作用。ATM可能作为淋巴结阴性乳腺癌患者预后判断的指标。
Objective To study the expression of ATM in lymph node - negative breast cancer and its relation to the pathological features and prognosis of lymph node - negative breast cancer. Methods Immunohistochemical staining of ATM was performed by the standard streptavidin peroxidase（SP） technique for the paraffin section of 64 lymph node - negative breast cancers and 48 breast benign tumor and normal breast tissue. Results The positive expression rate of ATM in 64 cases of lymph node - negative breast cancer was 53. 1% ,whereas the positive expression rate of ATM in 48 breast benign tumor and normal breast tissue were 72.9% , and the difference between them was significant（ P =0. 033）. The expression of ATM was correlated with HER2 status（P =0. 028） , but had no significant correlation with histological type, tumor location, age, tumor size, ER/PR status, P53 expression and the overall survival of patients. Conclusion The decrease of ATM expression may play an important role in the development of lymph node - negative breast cancer. ATM may be used as a maker for prediction of the prognosis of patients with lymph node - negative breast cancer.
出处
《医学研究杂志》
2012年第9期40-43,共4页
Journal of Medical Research
基金
国家自然科学基金资助项目(81072175)
国家自然科学基金青年项目(81102010)
2010年上海市卫生局科研计划(2009113)
关键词
乳腺癌
淋巴结阴性
ATM
Breast cancer
Lymph node - negative
ATM
