摘要
目的：了解髋日骨折患者血清炎症因子变化与临床意义。方法：对23例复杂髋臼骨折患者的白细胞介素-1（IL－1β）、血清肿瘤坏死因子-α（TNF-β）及可溶性血管细胞间粘附分子-1（sVCAM-1）水平进行检测（实验组I）。并与21例简单髋臼骨折患者（实验组2）和20侧健康体检者（对照组）比较。结果：实验组的IL—1β、TNF—α和sVCAM-1水平高于对照组（P〈0．01），实验组1的sVCAM—1水平又高于实验组2（P〈0．01）。结论：髋臼骨折患者其机体内皮功能受损，巨噬细胞被活化．引起多种细胞园子的释放，这种变化可能与患者常见的深静脉血栓并发症的发生有关。
Objective To find out the change of serum inflammation factor level and their clinical significance in pations with fracture of the acetabulum. Methods serum of interleukin - 1 （ IL - 1 β） ,tumor necrosis factor - α（TNF - α） , soluble vascular cell adhesion molecule - 1 （ sVCAM - 1 ） in 23 patients with complicated fracture of the acetabulum （gruupl） and 21 simple fracture of the acetabulam（gronp2） and 20 normal controls. Result the level of IL- 1 [3 ,TNF -c t, sVCAM -1 increased significantly in patient in gruupl than in normal controls, the difference was significant （ p 〈 0.01 ）, and the level of sVCAM - 1 increased sigeificantly in patient in gruupl than in group 2,the difference was significant （p 〈 0.01 ）. Conclusion We evaluated the function of endothelial cells were damaged, in which activate the macruphage,release the inflammation factor, and this can be likely to play an important role in the aetiology of deep venous thrombosis （DVT） in the patients with fracture of the acetabulum.
出处
《成都医学院学报》
CAS
2012年第02Z期2-2,共1页
Journal of Chengdu Medical College
基金
百色市科技局资助项目（2006-10-11）
