摘要
目的设计、开发一种新型的具有潜在抗肿瘤活性的4-羟基喹啉-2-酮的合成工艺。方法以芳醛和4-羟基喹啉-2-酮为原料，在微波辐射条件下一锅法合成了目标产物。结果产物的结构通过核磁共振氢谱、红外光谱进行了确证。结论本文所报道的合成路线具有反应条件温和，无催化剂，路线短等优点，最终以较高产率获得了目标化合物。
Objective To design and synthesize a series of bis（4 -hydroxyl- 2 -oxoquinoline -3 -yl） arylmethane derivatives which may have potential antitumor activity. Methods The target product was synthesized by one - pot condensation of aromatic aldehyde and 4 - hydroxyquinoline - 2 - one under microwave irradiation. Results The structure of the product was confirmed by ： H NMR and IR spectra. Conclusion The reaction has the advantages of short reaction time （10 -15 min） , good to excellent yields, easy work- up and being environmentally friendly.
出处
《徐州医学院学报》
CAS
2012年第9期578-580,共3页
Acta Academiae Medicinae Xuzhou
基金
基金项目：江苏省大学生科技创新课题（2011-1000）
关键词
无催化剂
芳醛
4-羟基喹啉-2-酮
潜在抗肿瘤活性
without catalyst
aromatic aldehyde
4 - hydroxyquinoline - 2 - one
potential antitumor activity
