摘要
目的观察DCF方案和OLF方案治疗晚期胃癌的临床疗效和不良反应。方法 92例晚期胃癌患者随机分为2组,其中DCF组43例,OLF组49例。DCF方案:多烯紫杉醇35 mg/m2,静脉滴注,第1天及第8天;顺铂25 mg/m2,静脉滴注第2～4天;5-氟尿嘧啶500 mg/m2,持续静脉泵入,第1～5天,3周为1个周期。OLF方案:奥沙利铂130mg/m2,静脉滴注3 h,第1天;亚叶酸钙200 mg/m2,静脉滴注第1～5天;5-氟尿嘧啶500 mg/m2在亚叶酸钙后静脉滴注3 h,第1～5天,3周为1个周期。2组均治疗2个周期以上,按WHO标准评价客观疗效和不良反应。结果入组的92例患者均可评价疗效,DCF组有效率46.5%,中位进展时间为6.8个月,中位生存时间11.4个月;OLF组有效率32.7%,中位进展时间为5.1个月,中位生存时间10.1个月。不良反应中外周神经炎的发生率以OLF组显著(P<0.05),其余不良反应发生率差异无统计学意义。结论 DCF方案与OLF方案治疗晚期胃癌疗效确切,其中以DCF方案疗效略高,不良反应均能耐受。
Objective To evaluate the efficacy and toxicity of regimen DCF versus OLF in the treatment of advanced gastric cancer.Methods Ninety-two cases with advanced gastric cancer were enrolled in this study,randomly divided into DCF group（43 cases）and OLF group（49 cases）.DCF group was treated with docetaxel 35 mg/m2,ivqtt,d1,8;cisplatin 25 mg/m2,ivqtt,d 2～4;5-fluorouracil 500 mg/m2 infused with an ambulatory pump on day 1 to 5,repeated every 3 weeks.OLF group was treated with oxaliplatin,ivqtt,d1;lencovorin 200 mg/m2,ivqtt,2hr,d1-5 followed by 5-fluorouracil 500 mg/m2,ivqtt,3hr,d1-5,repeated every 3 weeks.All patients received two cycles of chemotherapy at least.The efficacy and toxicity were evaluated according to WHO standard.Results All 92 cases were evaluable for objective response.In DCF group,the overall response rate was 46.5%,the median time to progression（mTTP） was 6.8 months and the median survival time was 11.4 months.In OLF group,the overall response rate was 32.7%,the median time to progression was 5.1 months and the median survival time was 10.1 months.The incidence of peripheral neuritis in OLF group were significantly higher than the DCF group（P〈0.05）.The other side effect had no statistical difference between two groups.Conclusion Both of the two regimen are fesible,well tolerated and effective in the treatment of advanced gastric cancer.DCF regimen is more effective than OLF regimen which merits further study.
出处
《实用癌症杂志》
2012年第5期482-485,共4页
The Practical Journal of Cancer
