摘要
自1981年人类免疫缺陷病毒1型（HIV-1）被发现以来,尽管科研工作者在HIV感染的阻断及AIDS病毒治疗方面都取得了一些成绩,但尚未从疫苗角度解决HIV感染的问题,其瓶颈是没有一种有效的疫苗能调动机体产生强大的抗病毒感染能力。解决这一问题的希望之一是设计优良的疫苗抗原,以诱导出针对HIV流行株的广谱中和抗体。
The induction of potent and broad-spectrum neutralizing antibodies （NAbs） against HIV remains a major challenge in the current AIDS vaccine research. During the past years, only four broad-spectrum neutralizing monoclonal antibodies（MeAbs）had been defined. Recently, more than a dozen of McAbs with substantial spectrum and potent inhibition have been identified. The HIV envelope glycoprotein is the main target of NAbs and also the key antigenic site of the HIV vaccine to induce NAbs. The native HIV envelope glycoprotein only bears very weak immungenicity to induce the NAbs and therefore, different strategies and methods have been applied to optimize this protein in order to construct more effective vaccines to induce potent NAbs against HIV.
出处
《中国病毒病杂志》
CAS
2012年第5期321-325,共5页
Chinese Journal of Viral Diseases
基金
国家"十二五"艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2012ZX10004701001)
关键词
HIV膜蛋白
中和抗体
抗原改造
HIV envelope glycoprotein
Neutralizing antibody
Antigen modification
