80岁及以上晚期非小细胞肺癌患者一线化疗的临床观察
被引量:4
摘要
随着肺癌发病率的上升以及人口的老龄化,老年肺癌患者的人数也相应增加。已有的关于老年非小细胞肺癌化疗的临床研究,选择的多数是80岁以下的患者,80岁及以上的非小细胞肺癌患者,主要脏器功能往往相对低下,合并症较多,为了更多了解这部分患者化疗的疗效及耐受性,本文分析了80岁及以上有较好体力状态和脏器功能,无EGFR基因突变或基因突变不详的晚期非小细胞肺癌一线单药化疗的临床资料,现报告如下。
出处
《中国临床保健杂志》
CAS
2012年第5期538-539,共2页
Chinese Journal of Clinical Healthcare
参考文献9
-
1Owonikoko TK, Ragin CC, Belani CP, et al. Lung cancer in elderly patients : An analysis of the surveillance, epide- miology, and end resuhs database [ J ]. J Clin Oncol, 2007,25 ( 35 ) :5570-5577. 被引量:1
-
2Ahundaq O, Stewart DJ, Fossella FV, et al. Many patients 80 years and older with advanced non-small cell lung cancer(NSCLC) can tolerate chemotherapy [ J ]. J Thorac Onco1,2007,2 ( 2 ) : 141-146. 被引量:1
-
3Weiss J, Stinchcombe TE. Treatment of elderly patients with stage Ⅳ non-small cell lung cancer [ J ]. Expert Rev Anticancer Ther,2012,12( 1 ) : 111-120. 被引量:1
-
4Earle CC, Tsai JS, Gelber RD, et al, Effectiveness of chemotherapy for advanced lung cancer in the elderly:in- strumental variable and propensity analysis [ J ]. J Clin Oneo1,2001,19(4) : 1064-1065. 被引量:1
-
5Hesketh PJ, Lilenbaum RC, Chansky K, et al. Chemother- apy in patients > or = 80 with advanced non-small cell lung cancer : combined results from SWOG 0027 and LUN 6[ J]. J Thorac 0ncol,2007,2(6):494-498. 被引量:1
-
6Fisher MD, D' Orazio A. Phase Ⅱ and Ⅲ trials : compari- son of four chemotherapy regimens in advanced non small cell lung cancer (ECOG 1594) [ J ]. Clin Lung Cancer, 2000,2 (1) :21-22. 被引量:1
-
7Ganti AK, Deshazo M, Weir AB, et, al. Treatment of non- small cell lung cancer in the older patient [ J ]. J Natl Compr Canc Netw,2012,10 (2) : 230-239. 被引量:1
-
8Langer CJ,Vangel M,Schiller J ,et al. Age-specific sub-a- nalysis of ECOG 1594 : Fit elderly patients ( 70-80 years) with NSCLC do as well as younger patients ( < 70) [ J ]. Proc Am Soc Clin 0ncol,2003,22(3) :639. 被引量:1
-
9刘鹏,冯奉仪,石远凯.老年晚期非小细胞肺癌化疗的临床分析(附29例报告)[J].北京医学,2009,31(9):523-525. 被引量:1
二级参考文献14
-
1Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol, 2001,29:533-43. 被引量:1
-
2Gridelli C. Does chemotherapy have a role as palliative therapy for unfit or elderly patients with non-small cell lung cancer? Lung Cancer, 2002,38(Suppl):S45-S50. 被引量:1
-
3Bunn PA, Lilenbaum R. Chemotherapy for elderly patients with advanced non-small-cell lung cancer. J Natl Cancer Inst, 2003,95:341-343. 被引量:1
-
4Ries LAG, Eisner MP, Kosary CL, et al. SEER cancer statistics review 1975 - 2000. J Nail Cancer Inst, 2003,95:1276-1299. 被引量:1
-
5Montella M, Gridelli C, Crispo A, et al. Has lung cancer in the elderly different characteristics at presentation. Oncol Rep, 2002,9: 1093-1096. 被引量:1
-
6Gridelli C, Cigolari S, Gallo C, gemcitabine and gemcitabine et al. Activity and toxicity of + vinorelbine in advanced non-small-cell lung cancer elderly patients: phase II data from the Multicenter Italian Lung Cancer in the Elderly Study (MILES) randomized trial. Lung Cancer, 2001,31:277-284. 被引量:1
-
7Balducci L. Management of cancer in the elderly. Oncology, 2006,20:135-152. 被引量:1
-
8Kelly K, Crowley J, Bunn PA, et al. Randomized phase III trial of paclitaxel plus carboplatin versus vinorelbine plus cisplatin in the treatment of patients with advanced non-small cell lung cancer:, a Southwest Oncology Group trial. J Clin Oncol,2001,19:3210-3218. 被引量:1
-
9Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small cell lung cancer. N Engl J Med,2002,346:92-98. 被引量:1
-
10Firvida JL, Amenedo M, Rodriguez R,et al. Docetaxel plus fractionated cisplatin is a safe and active schedule as first-line treatment of patients with advanced non-small cell lung cancer:results of a phase II study. Invest New Drugs, 2004,22:481-487. 被引量:1
同被引文献36
-
1李民,张利萍,吴新民.右美托咪啶在临床麻醉中应用的研究进展[J].中国临床药理学杂志,2007,23(6):466-470. 被引量:483
-
2Gazzeri S.P53 genetic abnormalities and mycactivati on in human lung carcinoma. Int J Cancer, 1994, 58(1):24-32. 被引量:1
-
3Aqeilan RI, Pekarsky Y, Herrero JJ, et al. Functional ass-ociation between WWOX tumorsuppressor protein and p73, a P53 homolog. Proc NatlAcad Sci USA, 2004, 101(13):4401-4406. 被引量:1
-
4Ludes-Meyers JH, KiI H, Bednarek AK, et al. WWOX binds the specific proline-rich ligand PPXY: identificati on of can-didate interacting proteins. J Oncogene, 2004, 23(29): 5049-5055. 被引量:1
-
5Palakodeti A, Han Y, Jiang Y, et al. The role of late/slow replication ofFP, A16D in common fragile site induction. Genes Chromosomes Cancer, 2004, 39(1):71-76. 被引量:1
-
6Donati V, Fonta nini G , Dell-Omodarme M, et al. WWOX expression in different histologic types and subtypes of non-small cell lung cancer. J Clin Cancer Res, 2007, 13(3): 884-891. 被引量:1
-
7Kraemer-Pecore CM, Lecomte JT, Desjarlais JR. A denovo redesign of the WWOX domain. Protein Sci, 2003, 12(10):2194-2205. 被引量:1
-
8Nunez MI, Ludes-Mevers J, Abba MC, et al. Frequem loss of WWOX expression in breast cancer:correlation with estrogen receptor status. J Breast Cancer Res Treat, 2005, 89:99-105. 被引量:1
-
9Fabbri M, lliopoulos D, Trapasso F, et al. WWOX gene restoration prevents lung cancer growth in vitro and in vivo. PNAS, 2005, 102(43): 15611 - 15616. 被引量:1
-
10Voepel-Lewis T,Malviya S,Tait A R. A prospective cohort study of emergence agitation in the pediatric postanesthesia care unit. Anesthesia \& Analgesia,2003,96(6):1625-1630. 被引量:1
引证文献4
-
1王军.WWOX蛋白在非小细胞肺癌中的表达及临床意义[J].浙江临床医学,2012,14(12):1457-1459. 被引量:1
-
2施乐贞,陈骏萍.不同剂量右美托咪定对肺癌根治术患者苏醒期的影响[J].浙江临床医学,2013,15(6):789-791. 被引量:9
-
3李琳,别志欣,张萍,王晖,张子瑾,武小楠,程刚.高龄晚期非小细胞肺癌患者112例临床分析[J].中国临床保健杂志,2014,17(5):536-538. 被引量:9
-
4朱小明,梁勤凤,王祥瑜,李倩倩,王莉.心理干预对中年肺癌患者焦虑和抑郁状况的影响[J].中国临床保健杂志,2016,19(4):417-418. 被引量:7
二级引证文献26
-
1梁亚贵,翁迪贵,蒋润年,黄清庆.右美托咪定在老年七氟醚全麻手术患者中的应用效果观察[J].齐齐哈尔医学院学报,2013,34(21):3159-3160. 被引量:3
-
2张冬妮,陈骏萍.腰-硬联合麻醉用于高龄患者下肢手术的临床观察[J].中国现代医生,2014,52(10):70-72. 被引量:6
-
3张冬妮,陈骏萍.硬膜外复合全麻在妇科腹腔镜手术中麻醉效果分析[J].中国现代医生,2014,52(11):67-69. 被引量:11
-
4田利,杜晓媛.非小细胞肺癌中Bmi-1和WWOX蛋白的表达及其临床意义[J].解剖科学进展,2014,20(4):364-367.
-
5朱红英.高龄患者下肢手术应用腰-硬联合麻醉的临床体会[J].中国现代药物应用,2014,8(20):128-129.
-
6陈大广,张捷,彭海燕,陈晓凤.右美托咪定对肺癌根治术患者全麻苏醒期躁动及血流动力学的影响[J].黑龙江医学,2015,39(12):1340-1341. 被引量:4
-
7庞希友.不同浓度右美托咪定应用于老年肺叶切除术对患者应激性反应的影响[J].中华全科医学,2016,14(1):57-59. 被引量:5
-
8王帅,董玲玲,罗南,王安全,刘洪星.GP化疗方案治疗高龄非小细胞肺癌的临床疗效观察[J].实用心脑肺血管病杂志,2016,24(2):76-78. 被引量:6
-
9周汝虹,李洪,张旭,罗远国.不同剂量右美托咪定对老年肺癌根治术患者免疫功能及苏醒期应激反应的影响[J].医学综述,2016,22(7):1394-1396. 被引量:16
-
10朱小明,梁勤凤,王祥瑜,李倩倩,王莉.心理干预对中年肺癌患者焦虑和抑郁状况的影响[J].中国临床保健杂志,2016,19(4):417-418. 被引量:7
-
1朱斌.CAG方案治疗老年急性髓系白血病的疗效分析[J].求医问药(下半月刊),2012,10(2):296-296.
-
2陈振东.非小细胞肺癌化疗中的难题[J].中国社区医学,2002,8(3):42-43.
-
3孙亚川.非小细胞肺癌化疗现状[J].西藏医药,2002,23(3):29-29. 被引量:1
-
4Ruekdesehel J C,李全新,佟学一.对转移的非小细胞肺癌化疗是否值得?[J].国外医学(肿瘤学分册),1991,18(3):178-180.
-
5肖红.非小细胞肺癌化疗的整体护理[J].现代医药卫生,2009,25(16):2519-2520.
-
6陈方红,王剑,黎启菊.紫杉醇联合奥沙利铂或顺铂治疗晚期非小细胞肺癌疗效观察[J].西南国防医药,2012,22(3):268-271. 被引量:5
-
7郭其森.非小细胞肺癌化疗研究进展[J].山东医药,2003,43(35):51-52. 被引量:6
-
8吴福道,邓国忠,伍显庭,方向东,桂金川.参附注射液对恶性肿瘤化疗所致白细胞下降及体力状态的影响[J].华西药学杂志,2000,15(6):474-474. 被引量:17
-
9刘沙.康莱特在老年晚期非小细胞肺癌化疗中的应用效果[J].当代医学,2016,22(28):157-158. 被引量:2
-
10陈楠,林忠,吕维泽.吉西他滨联合奈达铂双周方案治疗晚期非小细胞肺癌的临床观察[J].中外医疗,2013,32(35):102-103. 被引量:2