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氯沙坦对维持性血液透析患者脑钠素的影响

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摘要 目的:观察氯沙坦对维持性血液透析(MHD)患者脑钠素(BNP)水平的影响。方法:选取伴有高血压的MHD患者48例,随机分为安慰剂组和氯沙坦组,安慰剂组每位患者每日口服安慰剂,氯沙坦组每位患者口服氯沙坦50~100mg/d,两组分别于治疗前、后3个月分别测定BNP水平。结果:与实验前相比,实验后1个月氯沙坦组BNP明显降低,差异具有统计学意义[(992.4±238.9)pg/mlVS(618.5±243.6)pg/ml,P<0.01],而安慰剂组无明显变化[(978.3±226.5)pg/mlVS(989.7±235.1)pg/ml,P>0.05]。结论:氯沙坦可降低MHD患者BNP水平,从而减少心血管病发生的风险,提高患者的生活质量,其具体机制有待于进一步研究。
出处 《中国中西医结合肾病杂志》 2012年第9期813-814,共2页 Chinese Journal of Integrated Traditional and Western Nephrology
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