摘要
目的观察叶酸对2型糖尿病患者血清8-异前列腺素F1α（8-IPF2α）和6-酮前列腺素F2α（6-K-PGF1α）的影响，探讨叶酸对2型糖尿病患者氧化应激的影响。方法98例口服降糖药治疗的2型糖尿病患者随机分为2组，完成试验88例，试验组42例，对照组46例。对照组继续给予降糖治疗；试验组在原降糖治疗的基础上，加用叶酸5mg口服，3次／d。治疗前和治疗3个月后测定2组患者血清同型半胱氨酸（Hcy）、叶酸、8-IPF2α、6-K-PGF1α水平。结果治疗3个月后，试验组患者血清叶酸、6-K-PGF1α高于对照组[（13．3±2．6）pmol／L比（11．5±2．4）pmol／L，（84±14）ng／L比（70±12）ng／L，P〈0．05]，血清Hey、8-IPF2。低于对照组[（9．2±2．3）μmol／L比（11．1±2．8）μmol／L、（21±3）ng／L比（35±7）ng／L，P〈0．05或P〈0．01]。结论叶酸对2型糖尿病患者有抗氧化应激的作用。
Objective To explore the effects of folate on changes of 8-isoprostane F2α（8-IPF2α）, 6-keto- prostaglandin-F1α （6-K-PGF1α） and oxidative stress in patients with type 2 diabetes mellitus. Methods Ninety- eight patients with type 2 diabetes mellitus on oral hypoglycemic drugs were randomly divided into two groups; 88 of 98 subjects completed the study. There were 46 participants （control group） who received a 3-month course of oral hypoglycemic drugs;the remaining 42 patients （experiment group ） received oral hypoglycemic drugs and folate 15 mg daily. Serum Hcy, folate, 8-IPF2α, 6-K-PGF1α were measured at baseline and after treatment. Results There was no significant difference in clinical data and serum Hcy, folate, 8-IPF2α, 6-K-PGF1α between two groups before treatment. Compared with the control group, experiment group with folate showed a significant increase in serum folate [ （ 13. 3 ± 2. 6） pmol/L vs （ 11.5 ± 2. 4） pmol/L, P 〈 0. 05 ] and 6-K-PGF1α [ （ 84 ± 14） ng/L vs （70 ± 12） ng/L, P 〈 0. 05 ] and decreased in serum Hcy [ （ 19. 2 ± 2. 3 ） μmol/L vs （ 11.1 ± 2. 8 ）μmol/L, P 〈 0.05 ] and 8-IPF2α [ （21 ± 3 ） ng/L vs （ 35 ± 7 ） ng/L, P 〈 0. 01 ]. Conclusion The administration of folate reduces oxidative stress in type 2 diabetes mellitus.
出处
《中国医药》
2012年第10期1236-1238,共3页
China Medicine
