摘要
目的观察丁基苯酞治疗急性脑梗死效果及磁共振波谱特征,探讨丁基苯酞可能的作用机制。方法发病在72h内的急性脑梗死病人80例,随机分为治疗组(n=42)和对照组(n=38),对照组接受常规治疗,治疗组在常规治疗的基础上加用丁基苯酞胶囊。两组病人均于治疗前、治疗15和30d后进行神经功能缺损程度评分及BARTHEL指数评定,并应用磁共振波谱分析入院时(治疗前)、治疗30d后脑内N-乙酰天门冬氨酸(NAA)和乳酸(Lac)含量。结果治疗组治疗15、30d的神经功能缺损程度评分低于对照组,BARTHEL指数评分高于对照组,差异有显著性(t=-4.82～4.38,P<0.01)。磁共振波谱分析显示,治疗后治疗组局部Lac含量低于对照组,NAA含量高于对照组,差异有显著性(t=-3.45、4.62,P<0.01)。结论急性脑梗死病人采用丁基苯酞治疗能够显著改善临床预后,其作用机制可能与加速梗死区Lac清除有关。
Objective To observe the therapeutic effect of butylphthalide on patients with acute cerebral infarction（ACI） and the features of magnetic resonance spectrum（MRS）,to explore the potential mechanism of action of butylphthalid.MethodsThis study consisted of 80 patients with ACI occurred within 72 h,who were randomized to treatment group（n=42） and control group（n=38）.A conventional therapy was offered to patients in the control group;to those in the treatment group,conventional therapy plus butylphthalide were offered.Neurologic impairment and BARTHEL were assessed pretherapy and 15 and 30 days after therapy.The content of N-acetylaspartate and lactic acid before treatment and 30 days after were analyzed using MRS.Results After 15 and 30 days of treatment,the score of neurologic impairment was lower in the treatment group than that in the control group,and the BARTHEL index was higher（t=-4.82-4.38,P〈0.01）.The MRS showed that after therapy,the level of lactic acid in the treatment group was lower than that in the control group,and N-acetylaspartate was higher（t=-3.45,4.62;P〈0.01）.Conclusion Butylphthalide can notably improve the prognosis of patients with ACI,its mechanism is likely to be associated with accelerating clearance of lactic acid in infarct zone.
出处
《青岛大学医学院学报》
CAS
2012年第6期471-472,475,共3页
Acta Academiae Medicinae Qingdao Universitatis
关键词
丁基苯酞
脑梗死
治疗结果
磁共振波谱学
butylphthalide
brain infarction
treatment outcome
magnetic resonance spectroscopy
