摘要
目的 :探讨肝血管平滑肌脂肪瘤的临床病理学特点、诊断和鉴别诊断要点。方法 :复习 10例肝血管平滑肌脂肪瘤 (Aml)临床资料 ,并用石蜡切片进行组织化学、免疫组化检测 ,2例进行电镜观察。结果 :10例Aml中 8例女性 ,2例男性 ,平均年龄44岁。临床无症状 ,而是影像学检查偶然发现。大体上为境界清楚但无包膜的肿块。光镜下由 3种成分即厚壁血管、上皮样或梭形平滑肌细胞及脂肪混合组成 ,偶尔还可见髓外造血成分。免疫组化检查瘤细胞表达A10 3、HMB45及平滑肌标记。结论 :Aml组织学形态变化多样 ,3种主要成分的比例和分布各异。检测A10 3和HMB45有助于确诊。
Purpose To investigate the clinicopathologic characteristics and differential diagnosis of hepatic angiomyolipoma (Aml). Methods Ten cases of Aml were retrieved and analyzed morphologically,and were performed on paraffin embedded tissues with a panel of antibodies, including antibody A103. Two cases of them were observed by electron microscopy. Results There were eight women and two men, with age ranged 38～58 years (median 44 years). Clinically, nine cases were asymptomatic and found by imaging techniques. None of the patients were associated with tuberous sclerosis. All tumors were well circumscribed. Histologically they were composed of a varying heterogeneous mixture of three components: thick walled blood vessels, spindle or epithelioid smooth muscle cells and adipose tissues. All tumors showed strong immunoreactivity to A103, HMB45 and smooth muscle actin. Followed up information of all 10 cases showed a benign course with no signs of recurrences. Conclusion Hepatic Aml is a rare mesenchymal tumor of the liver. A103 and HMB45 are a promising marker in diagnosis of hepatic angiomyolipoma.
出处
《临床与实验病理学杂志》
CAS
CSCD
2000年第3期192-195,共4页
Chinese Journal of Clinical and Experimental Pathology
