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阿托伐他汀治疗糖尿病早期肾病的疗效观察 被引量:4

Effects Of Atorvastatin in the Treatment of Early Diabetic Nephropathy
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摘要 目的观察阿托伐他汀治疗糖尿病早期肾病的疗效。方法选择我院2008年—2010年住院的糖尿病早期肾病患者48例,随机分为治疗组和对照组,各24例。比较两组患者治疗前及治疗6个月后的血生化指标及药物不良反应。结果治疗后治疗组尿微量清蛋白、血肌酐、超敏C反应蛋白与对照组比较,差异均有统计学意义(P<0.05)。结论阿托伐他汀能降低糖尿病早期肾病患者的尿微量清蛋白、超敏C反应蛋白,改善肾功能。 Objective To observation of the effects of atorvastatin in the treatment of early diabetic nephropathy. Methods Our hospital foom 2008 to 2010 in hospitalized diabetic patients with early diabetic nephropathy 48 eases, were ran- domly divided into treatment group and control group, 24 cases in each. Comparison of the two groups before treatment and after treatment for 6 months, blood biochemical index and adverse drug reaction. Results After treatment, the treatment groupuri- nary albumin, serum ereatinine, high sensitivity C reactive protein in comparison with the control group, the difference was sta- tistically significant (P 〈0. 05). Conclusion Atorvastatin reduced the early diabetic nephropathy patients with microalbumin- uria, high sensitivity C reactive protein, improve renal function.
作者 肖宁
出处 《实用心脑肺血管病杂志》 2012年第10期1660-1660,1662,共2页 Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词 糖尿病肾病 阿托伐他汀 治疗结果 Diabetic nephropathy Atorvastatin Treatment outcome
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  • 1Nakamura T, Ushiyama C, Hirokwa K, et al. Effect of cerivastatin on urinary albumin excretion and plasma endothelin- 1 concentations in type2 diabetes patients with microalbuminuria and dyslipidemia. Am J Nephrol, 2001,21(6) :449 - 454. 被引量:1
  • 2Kim SI, Hah DC,Lee HB. Lovastatin inhibits transforming growth factor-β1 expression in diabetic rat glomeruli and cultured rat mesangial cells. J Am Soc Nephrol,2000,11(1):80-87. 被引量:1
  • 3Ota T, Takamura T, Ando E, et al. Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model. Diabetdogia, 2003,46 (6): 843 - 851. 被引量:1
  • 4Lee TM, Su SF, Tsai CH. Effect of pravastatin on proteinuria in patients with well- controlled hypertension. Hypertension, 2002,40 ( 1 ): 67 - 73. 被引量:1
  • 5Tesar V. Some important news in clinical nephrology in years 2003 - 2004. Vnitr Lek, 2004,50 (Suppl 1 ): 81 - 87. 被引量:1
  • 6Aika M, Rabikin E, Sugivama S, et al. An HMGCOA reductase inhibitor,cerivas- tatin,suppresses growth of macrophage expressing matrix metalloproteinases, and tissue factor in vivo and in vitro. Circulation, 2001,103:276 - 283. 被引量:1
  • 7Elisaf M, Mikhailidis DP. Statins and renal function. Angiology,2002,53(5) :493 - 502. 被引量:1
  • 8EpsteinM, Campese VM. Pleiotropic effects of 3 - hydroxy-3- methylglutary coenzyme a reductase inhisitors on renal funtion. Am J Kidney Dis, 2005,45 (1): 2 - 14. 被引量:1
  • 9苏颖,中华肾脏病杂志,1998年,14卷,215页 被引量:1
  • 10于力,中华肾脏病杂志,1997年,13卷,14页 被引量:1

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  • 1陆晔,郑杨,郭雁飞,李新建,程月华,何丽芸,徐继英,应韶旭,吴凡.上海市中老年人群中糖尿病发病与糖化血红蛋白基线值相关性的回顾性研究[J].实用老年医学,2013,27(1):35-37. 被引量:7
  • 2缪珩,李慧敏,蒋秀琴,陈家伟.阿托伐他汀对高糖培养人肾系膜细胞的作用[J].江苏医药,2005,31(4):255-257. 被引量:4
  • 3Wolf G,Reinking R,Zahner G,et al. Erk 1,2 phosphoryl-ates p27(Kipl) :Functional evidence for a role in high glu-cose-induced hypertrophy of mesangial cells[J]. Diabeto-logia,2003,46(8) :1090-1099. 被引量:1
  • 4Ding DF,You N,Wu XM,et al. Resveratrol attenuates re-nal hypertrophy in early-stage diabetes by activatingAMPK[J]. Am J Nephrol,2010,31(4) :363-374. 被引量:1
  • 5Wolf G,Schroeder R,Ziyadeh FN, et al. High glucosestimulates expression of p27Kipl in cultured mouse me-sangial cells:relationship to hypertrophy[J]. Am J Physi-01,1997,273(3 Pt 2):348-356. 被引量:1
  • 6Costa J,Borges M,David C,et al. Efficacy of lipid lower-ing drug treatment for diabetic and non-diabetic patients:meta-analysis of randomised controlled trials [J]. BMJ,2006,332(7550) :1115-1124. 被引量:1
  • 7Sattar N,Preiss D,Murray HM,et aI.Statins and risk of incident diabetes:a collaborative meta analysis of randomised statin trials[J] .Lancet, 2010,575(9716):755-742. 被引量:1
  • 8Maeda S.Do inflammatory cytokine genes confer susceptibility to diabetic nephropathy? [J].Kidney Int,2008,74(4):415-415. 被引量:1
  • 9Brunzell JD,Davidson M,Furberg CD,et al .Lipoprotein manacement in patients with cardfometabolic risk:consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation[J].J Am Coil Cardiol,2008,51(15):512-24. 被引量:1
  • 10Sanchez AP, Sharma K. Transcription factors in the pathogenesis of di- abetic nephropathy[ J]. Expert Rev Mol Med, 2009,11 :e13. 被引量:1

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