摘要
目的:探讨尿微量白蛋白(mALB)、视黄醇结合蛋白(RBP)和尿N-乙酰-β-d-氨基葡萄糖苷酶(NAG)检测对肝豆状核变性(HLD)早期肾脏损伤的诊断价值及其在不同类型HLD中测定值是否存在差异。方法:采用免疫比浊法检测尿mALB和RBP水平,采用连续监测法检测尿NAG水平。结果:各中医证型及西医临床分型HLD组尿mALB、RBP和NAG测定值均较正常对照组显著增高(P<0.01);而各中医证型及西医临床分型组组间mALB、RBP及NAG测定值比较,差异无统计学意义(P>0.05)。其在尿常规尿蛋白定性阴性HLD中阳性率分别为RBP94.74%、mALB78.07%和NAG35.09%。其中mALB与NAG呈正相关(r=0.26,P<0.01),mAL B与RBP水平呈正相关(r=0.232,P<0.01),NAG与RBP水平呈正相关(r=0.180,P<0.01)。结论:尿mALB、RBP和NAG检测对HLD早期肾损害具有诊断价值,其中RBP阳性率最高达94.74%。HLD各中医证型与西医临床分型间尿mALB、RBP和NAG水平无明显差异。
Objective： To survey diagnostic value of urinary micro-albumin （mALB）, retinol binding protein （RBP）, urinary N-acetyl β-d-glucosaminidase （NAG） detection on renal surgery in early times of hepatolenticular degeneration （HLD） and whether the difference existed in index of different HLD. Method： Levels of urinary mALB and RBP were detected with immunoturbidimetry and level of urinary NAG was tested with the continuous monitoring method. Result： Urinary mALB, RBP, NAG of TCM pattern and western medicine pattern groups were higher than normal control group （P〈0.01）; comparison among groups had no statistical meaning in mALB, RBP and NAG （P〉0.05）. Positive rates of HLD were respectively： RBP （94.74%）, mALB （78.07%） and MAG （35.09%）. mALB is positively associated to NAG （r=0.26, P＇〈0.01） and RBP （r=0.232,P〈0.01）, NAG is positively related to RBP （r=0.180, P〈0.01）. Conclusion： Urinary mALB, RBP and NAG show diagnostic value to renal injury in early time of HLD, among them, positive rate of RBP can reach to 94.74%. There is no significant difference among mALB, RBP and NAG in different patterns of HLD.
出处
《西部中医药》
2012年第9期117-119,共3页
Western Journal of Traditional Chinese Medicine
关键词
尿微量白蛋白
视黄醇结合蛋白
尿N-乙酰-Β-D-氨基葡萄糖苷酶
肝豆状核变性
早期肾损害
urinary micro-albumin
retinol binding protein（RBP）
urinary N-acetyl β-d-glucosaminidase（NAG）
hepatolenticular degeneration （HLD）
renal injury in early times
