摘要
目的观察银柴胶囊对脂肪肝的治疗作用。方法采用高脂饮食喂饲大鼠8周,建立非酒精性脂肪肝模型;实验分为银柴胶囊高、中、低剂量组、肝泰片组、模型组和正常饲养组;检测各组肝指数,血脂、肝转氨酶(ALT、AST),肝组织TC、TG及超氧化物歧化酶(SOD)和丙二醛(MDA)含量及肝病理学改变。结果非酒精性脂肪肝模型组与正常饲养组相比,肝指数、血脂、肝转氨酶、肝组织TC和TG均显著增高(均P<0.01),肝组织SOD明显降低(P<0.05),肝组织MDA明显增高(P<0.05),肝脏轻中度脂肪变性。银柴胶囊高、中剂量组与模型组相比,肝指数、血脂、肝转氨酶均显著下降(P<0.01);肝组织TC、TG明显下降(PTC<0.05,PTG<0.01)、SOD明显增高(P<0.05),MDA虽有下降,但无明显差异;肝细胞脂肪变性均有不同程度改善;与肝泰片组相比,无明显差异。银柴胶囊低剂量组与模型组相比,无明显差异。结论银柴胶囊可安全有效地用于非酒精性脂肪肝的治疗。
Objective To observe the treatment of Silver Chai capsules on non-alcoholic fatty liver rats. Methods Rats were fed with high fat diet for 8 weeks to establish the hyperlipi- demia and fatty liver models, and were derided into Silver Chai capsules high, middle, low dose groups and Gantai control group, model group, and normal group. Liver index, hepatic function, lipids, liver fat, liver superoxide dismutase （SOD）, the content of MDA, and liver histological changes were detected after different treatments. Results Hyperlipidemia and fatty liver group had higher liver index, hepatic function, lipids, liver fat （P 〈 0.01 ）, and a signif- icant decrease of SOD activity in liver （ P 〈 0.01 ）, rats in this group suffered from mild to moderate steatosis; Silver Chai capsules high, middle, low dose groups had significant decrea- ses on liver fat, hepatic function and lipids （ P 〈 0.01 ）, but an obvious increase of SOD activi- ty in liver （P 〈 0.05 ）, besides, livers in these groups of rats showed nearly normal. Conclu- sion Silver Chai capsules could be an effective treatment for non-alcoholic fatty liver.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2012年第4期350-353,共4页
Journal of Harbin Medical University
基金
黑龙江省科技厅国际合作项目(WB07C04)
哈尔滨市科技创新人才研究专项资金项目(2008RFXXS026)
关键词
高脂血症
脂肪肝
银柴胶囊
hyperlipidemia
fatty liver
Silver Chai capsules
