摘要
骨肉瘤好发于青少年,是一种发病率、致残率都很高的恶性肿瘤,而且预后差、易转移,严重威胁青少年的身心健康。骨肉瘤的发生、发展及转移是多因素、多步骤、多阶段和多基因改变的过程,涉及与生命活动相关的所有生物大分子,尤其是生物分子的异常调节。本文就骨肉瘤发生发展的分子机制进行探讨。
Osteosarcoma occurs in young people, has a very high incidence and disability, and poor prognosis, easy to transfer, a serious threat to physical and mental health. The incidence of osteosarcoma, development and metas- tasis is a multi - facto（, multi - step, multi - stage and multi - gene process of change, involving activities associat- ed with the life of all biological maeromoleeules, in particular, aberrant regulation of biological molecules. In this paper, the developmerit of osteosarcoma to explore the molecular mechanism.
出处
《生物信息学》
2012年第3期180-182,共3页
Chinese Journal of Bioinformatics
关键词
骨肉瘤
分子机制
抑癌基因
破骨细胞
微血管形成
osteosarcoma
molecular mechanism
cancer suppressor genes
osteoclast
angiogenesis
