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原发性醛固酮增多症患者血钾水平与血清肌酸激酶的相关性 被引量:4

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摘要 目的探讨原发性醛固酮增多症(PA)低钾型患者血清肌酸激酶的改变及其与低血钾的关系。方法回顾性分析58例确诊为PA患者按血钾高低分为低血钾组(33例)和血钾正常组(25例),收集临床和实验室检查资料,观察其血清肌酸激酶改变与血钾的关系。结果 33例PA低血钾患者均有不同程度肌无力,33例患者中21例(63.6%)伴肌酸激酶(CK)升高,1例CK最高为1 837 U/L,达正常的9倍以上,伴明显的腓肠肌疼痛,临床诊断横纹肌溶解;同时伴有肌电图的异常。25例PA血钾正常患者CK无明显异常。低血钾组较血钾正常组CK升高,差异有统计学意义[(270.4±98.9)vs(61.5±40.1)U/L,P<0.05)],CK升高的程度与血钾水平呈负相关(r=-0.78,P<0.00)。结论低血钾组PA患者的血钾水平与肌酸激酶呈负相关,要注意患者的肌肉无力症状和CK水平,慎防发生横纹肌溶解。
出处 《广东医学》 CAS CSCD 北大核心 2012年第18期2772-2773,共2页 Guangdong Medical Journal
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