摘要
目的探讨重症药疹的发病特点、临床特征及预后的相关因素。方法对本科1996年7月-2010年3月收治的45例重症药疹患者的临床资料进行回顾性分析。结果致敏药物以抗生素最为常见,其次为解热镇痛药,中药过敏者数量多于以往文献报道;别嘌醇所致药疹潜伏期长,重症多形性红斑型为最常见的重症药疹。死亡3例,死因主要为感染和脏器衰竭。结论早期足量使用糖皮质激素有助于病情的控制,联用人免疫球蛋白对危重患者有效;预后与年龄、皮损范围、糖皮质激素的应用、有无继发感染和基础疾病及严重程度密切相关。
Objective To explore the occurrence regularity, clinical manifestation, diagnosis, treatment experience and prognosis of severe drug eruption（SDE）. Methods A retrospective analysis was carried out on the clinical data of 45 patients suffered from drug eruption and admitted to our hospital from 1996 to 2010. Results Antibiotics and nonsteroidal anti-inflammatory drugs were the most common causative drugs, the number of allergies to Chinese traditional medicine was larger than the previous reports, allopurinol-induced severe drug eruption had longer latent period, erythema multiforme major was the most common pattern. Three cases died of pulmonary infection and multiple organ failure. Conclusion It is important to give sufficient corticosteroid treatment in early stage. Intravenous immunoglobulin combined with cortieosteroid was a good treatment option for some severe eases. It is suggested that the prognosis of SDE is determined by multi-factors such as patient＇ s age, lesion area, the dosage of systemic corticosteroid, pulmonary infection and systemic diseases and so on.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2012年第10期904-906,共3页
The Chinese Journal of Dermatovenereology
关键词
重症药疹
临床分析
Severe drug eruption
Clinical manifestation
