摘要
目的探讨不同年龄特发性膜性肾病（IMN）患者的临床与病理特点。方法选取两组经肾穿刺活检确诊的特发性膜性肾病患者，共109例，根据年龄分为青年组47例（年龄≤40岁）和老年纽62例（年龄≥65岁），比较两组患者的临床与病理特点。结果青年组男21例，女26例，年龄15—40岁，平均（32±13）岁；老年组男32例，女30例，年龄65～80岁，平均（68±11）岁，两组男女比例比较差异无统计学意义（P〉0．05）；青年组高血压病、镜下血尿发生率低于老年组，差异有统计学意义（P〈0．05）；青年组血清肌酐水平低于老年组，差异有统计学意义（P〈0．05）；两组患者24h尿蛋白定量、白蛋白、血清尿酸、血胆固醇、三酰甘油比较差异无统计学意义（P〉0．05）；青年组患者肾小管萎缩、间质纤维化、小动脉受累发生率低于老年组，差异有统计学意义（P〈0．05）。结论不同年龄特发性膜性肾病患者临床与病理表现有一定差异，临床治疗上宜对不同年龄患者制定个性化的方案。
Objeetive To investigate the clinical and pathological features of idiopathic membranous nephropathy in different age groups. Methods One hundred and nine patients, 47 cases in younger group（ ≤40 years）, and 62 eases in elder group（ ≥65 years）, diagnosed as IMN by renal biopsy, were enrolled in the study. The clinical and pathological results were compared between the two groups. Results Twenty-one male and 26 female younger patients with an average age was （32 ± 13 ）years （ 15 -40 years）, 32 male and 30 female elder patients with an average age was （ 68 ± 11 ） years （ 65 - 80 years ）, there was no difference in the sex ratio between the two groups （P 〉 0. 05）. The incidence of nephrotic syndrome, hypertention and mierohematuri in younger patients were lower than that in elder patients （P 〈 0. 05）. The level of serum creatinine in younger patients was lower than those in elder patients （P 〈 0. 05 ）. There was no difference in the levels of urine protein, serum albumin, uric acid, cholesterol or triglyeeride in patients between the two groups （P 〉 0. 05）. The incidence of renal tubular atrophy, interstitial fibrosis and arteriole lesion in younger group were lower than that in elder patients （P 〈 0. 05）. Conclusions The clinical and pathological features of idiopathic membranous nephropathy in different age groups were different, and pay attention to the diffefrences will help us in clinical treatment.
出处
《中国实用医刊》
2012年第20期15-17,共3页
Chinese Journal of Practical Medicine
关键词
特发性膜性肾病
青年
老年
临床特点
病理特点
Idiopathic membranous nephropathy
Younger
Elder
Clinical feature
Pathological feature
