摘要
目的观察奥美拉唑联合莫沙必利治疗返流性食管炎的疗效,分析其安全性。方法 2010年3月～2012年3月,92例食管返流病患者随机分为两组,观察组46例采用奥美拉唑联合莫沙必利治疗,对照组46例仅采用奥美拉唑治疗,比较观察两组的症状变化和临床疗效。结果与治疗前比较,两组治疗后烧心、反酸和胸骨后疼痛评分明显下降(P<0.05)。并且,观察组治疗后烧心、反酸和胸骨后疼痛评分均低于同期对照组,差异有统计学意义(P<0.05)。观察组的总有效率为93.5%,明显高于对照组(P<0.05)。结论奥美拉唑联合莫沙必利治疗返流性食管炎,能够明显提高治疗效果,并且安全性高,值得临床推广应用。
Objective To analyze the effect of omeprazole combined with mosapride on treatment of reflux esophagitis, and analyze its safety. Methods From March, 2010 to March, 2012, 92 cases of reflux esophagitis patients were randomly classified into two groups, observation group with 46 cases was treated with omeprazole combined with mosapride and control group with 46 cases was treated with omeprazole. The changes of main symptoms and clinical effect were compared. Results After treat- ment, the scores of heartburn, acid reflux and chest pain were significantly decreased （P 〈0.05） in both two groups. Moreover, the scores of heartburn, acid reflux and chest pain in observation group after treatment were significantly lower than those in control group （P 〈 0.05）. The total effective rates in observation group were 93.5%, significantly higher than that in control group （P 〈 0.05）. Conclusions Omeprazole combined with mosapride in treatment with reflux esophagitis can enhance clinical effect and has good safety, which can be applied in clinic.
出处
《齐齐哈尔医学院学报》
2012年第17期2348-2349,共2页
Journal of Qiqihar Medical University
