摘要
目的 探讨一贯煎联合西药治疗胃阴亏虚型糖尿病胃轻瘫的临床疗效。方法 将80例胃阴亏虚型糖尿病胃轻瘫患者随机分为治疗组和对照组各40例。两组均给予瑞格列奈片及盐酸二甲双胍片以控制血糖。治疗组加用一贯煎加减,每日1剂;对照组加用莫沙必利分散片,每次10mg,每日3次。两组均以2周为1个疗程。治疗前后及停药2周后进行中医证候评分并判断临床疗效,并于治疗前后计算胃半排空时间(GET1/2)及延迟时间(Tlag)。结果 两组治疗前后GET1/2及Tlag比较差异均有统计学意义(P<0.05或P<0.01);两组治疗后GET1/2及Tlag比较差异有统计学意义(P<0.01)。治疗组总有效率75.00%,对照组总有效率62.50%,治疗组优于对照组(P<0.05)。治疗组治疗后早饱、胃脘胀满、纳差、烧心、恶心呕吐、症状总积分与治疗前比较差异有统计学意义(P<0.01);对照组治疗后早饱、胃脘胀满、症状总积分与治疗前比较差异有统计学意义(P<0.05);治疗组治疗后与对照组比较,胃脘胀满、烧心、恶心呕吐、纳差比较差异有统计学意义(P<0.01);治疗组停药2周与对照组比较,早饱、胃脘胀满、纳差、舌象、脉象及症状总积分明显低于对照组(P<0.05或P<0.01)。结论 一贯煎联合西药治疗可以有效改善胃阴亏虚型糖尿病胃轻瘫患者临床症状,促进胃排空,临床疗效肯定。
Objective To observe the effect of Yiguan Brew （All-the-Way-Through Brew） combined with western medica tion on diabetic gastroparesis with stomach yin deficiency syndrome. Methods Eighty diabetic gastroparesis patients with stomach yin deficiency syndrome were randomized into treatment group and control group, with 40 in each. Both groups were given repaglinide and metformin hydrochloride tablets to control blood sugar. The treatment group was added with Yiguan Brew, one dose daily. The control group was added with Mosapride dispersible tablets, 10mg per time, 3 times daily. One treatment course lasted for 2 weeks. Scores of clinical symptoms, gastric half emptying time （GET1/2） and lag phase time （Tlag） were observed before and after treatment. Results After treatment, GET1/2 and Tlag improved significantly in both groups （P〈0.05 or P〈0.01）, especially in the treatment group （P〈0. 01）. The total effective rate of the treatment group and the control group was 75.00% and 62.50% respectively. The treatment group was superior （P〈0.05）. After treatment, there were significant differences in early satiety, epigastric fullness, loss of appetite, heartburn, nausea, vomiting and total symptom score in the treatment group as compared with before treatment （P〈0.01）. After treatment, there were significant differences in early satiety, epigastric fullness and total symptom score in the control group as compared with before treatment （P〈0.05）. After treatment, there were significant differences in epigastric fullness, heartburn, nausea, vomiting and loss of appetite between groups （P〈0.01）. Two weeks after treatment, early satiety, epigastric fullness, loss of appetite, tongue, pulse and total symptom score in thetreatment group were significantly lower than those in the control group （P〈0.05 or P〈 0.01）. Conclusion Modified Yiguan Brew could obviously relieve symptoms and promote gastric emptying for diabetic gasrop- aresis with stomach yin deficiency syndrome.
出处
《中医杂志》
CSCD
北大核心
2012年第18期1566-1569,共4页
Journal of Traditional Chinese Medicine
关键词
糖尿病胃轻瘫
养阴益胃疏肝法
胃阴亏虚型
一贯煎
diabetic gastroparesis
nourishing yin, boosting the stomach and coursing the liver
stomach yin de{iciency syn-drome
Yiguan Brew （All-the-Way-Through Brew）
