摘要
目的:探讨对终末期肾病患者行甲状旁腺切除对颈动脉钙化的影响。方法:选择我院2009年10月至2010年12月收治的20例继发性甲状旁腺功能亢进的终末期肾病患者,行甲状旁腺切除术,对患者术前、术后进行颈动脉彩超检查颈动脉钙化情况,并将患者术前、术后的血钙、血磷、钙磷乘积、PTH、C反应蛋白、血红蛋白、白蛋白等指标进行比较。结果:与术前比较,术后患者颈动脉钙化斑块有明显减少,血钙、血磷、钙磷乘积、PTH、C反应蛋白均明显降低,差异性有显著(P<0.05);血红蛋白较术前明显升高(P<0.05)。结论:切除甲状旁腺(PTX)能安全有效的降低甲状旁腺素水平、改善钙磷代谢紊乱,并控制颈动脉钙化的进展。
Objective： To investigate the impact ofparathyroidectomy on carotid calcification for patients with end stage renal dis- ease （ESRD）, and to evaluate the effect of parathyroidectomy on carotid calcification, calcium and phosphate abnormality of end-stage renal disease patients. Methods： 20 parathyroid patients with ESRD ofbyperparathyroidism from October, 2010 to October, 2011 in our hospital were excised and enrolled in this study. Carotid calcification was recorded before and after PTX. Meanwhile, the serum calcium, phosphorus, calcium-phosphate product, PTH, C-reactive protein, hemoglobin and albumin were compared before and after the surgery. Results： Compared with pre-operation, the serum calcium, phosphorus, calcium-phosphate product, PTH, C-reactive protein were signifi- cantly decreased in post-operation （P〈0.05）, and hemoglobin concentration was higher in post-operation than pre-operation （P〈0.05）. Conclusions： The removal of parathyroid glands （PTX） could rapidly and securely reduce the PTH, serum calcium levels and calci- um-phosphate product. It could prevent progression of vascular calcification and relieve the syndrome of patients with ESRD.
出处
《现代生物医学进展》
CAS
2012年第24期4711-4713,共3页
Progress in Modern Biomedicine
基金
深圳市龙岗区科技局科技计划项目(YS2011142)
关键词
终末期肾病
甲状旁腺切除术
颈动脉
钙化
End-stage renal disease （ESRD）
Parathyroidectomy
Carotid artery
Calcification
