摘要
最近研究显示，胰高血糖素样肽（GLP）．1与干细胞的定向分化功能有重要关系。其可明显提高干细胞向胰岛素分泌细胞的阳性诱导率，并增加诱导细胞对高糖刺激的反应性。推测这是由于GLP一1促进与胰腺功能和发育成熟相关的多种转录因子的高表达，增强G蛋白耦联受体（GPCRs）信号转导通路，激活G蛋白信号调节子（Rgs）16、Rgs8重新表达有关。体外利用GLP一1使干细胞定向分化为可分泌胰岛素的功能细胞，然后再进行自体移植，成为干细胞治疗糖尿病的一种新途径。
Recent evidence has shown that glucagon-like peptide-1 （GLP-1） plays an important role in targeted differentiation of stem cells. It can increase the differentiation rate of stem cells into insulin-produ- cing ones apparently, and improve the cells＇ reactivity to high glucose. This effect may be achieved by upregu- lating some critical transcription factors which are closely related with pancreatic functions and maturity, strengthening G protein-coupled receptor （GPCR） signaling pathways, and exciting the regulator of G-protein signaling（Rgs） 16 and 8 expressions. Thus GLP-1 may be used to induce differentiation of stem ceils into functional insulin producing-cells ex vitro for autologous transplantation. These findings provide new approa- ches to cure diabetes mellitus.
出处
《国际内分泌代谢杂志》
北大核心
2012年第5期314-317,共4页
International Journal of Endocrinology and Metabolism
基金
全军医学科技“十二五”科研资助项目（CWSllJ254）
