摘要
目的 研究慢性乙型肝炎 (CHB)患者庚型肝炎病毒 (HGV)感染的意义。方法 应用RT -PCR法对 14 6例CHB患者血清进行了HGV -RNA检测 ,并将HGV -RNA阳性与阴性患者进行临床与病理学对比。结果 HGV -RNA阳性 2 3例 ( 15 .75 % )。HGV -RNA阳性与阴性患者肝功能等生化指标水平、肝脏病理损害程度、HBV -DNA阳性率均无显著性差异 (P <0 .0 5 )。 5例HGV -RNA阳性、16例HGV -RNA阴性CHB患者干扰素的近期疗效无显著差异 (P >0 .0 5 )。结论 CHBHGV感染并不加重肝脏损害 ,亦不影响HBV的复制及干扰素的疗效 ;
Aim In order to study the significance of HGV infection in patients with chronic hepatitis B(CHB).Methods HGV-RNA were detected in serum samples from 146 patients with CHB by reverse transcription-polymerase chain reaction,the clinical and pathologic features of HGV-RNA positive patients were compared with those of HGV-RNA negative patients.Results Twenty three patients(15.75%) were positive for serum HGV-RNA,the rest were negtive.There were no significant differences in the level of liver function and other biochemical tests,HBV-DNA positive rate and the severity of liver pathologic lesions between the two groups(P>0.05).And same as in the short-term efficacy of interferon therapy to 5 HGV-RNA positive and 16 HGV-RNA negative patients (P>0.05). Conclusion HGV infection does not aggravate the liver lesions,HBV replication and response to interferon therapy of CHB.Pathogenicity of HGV is mild probably.
出处
《胃肠病学和肝病学杂志》
CAS
2000年第1期48-49,53,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
乙型肝炎
庚型肝炎病毒
RT-PCR
Hepatitis B Hepatitis G virus Reverse transcription-polymerase chain reaction
