摘要
目的探讨孕13～16周、孕17～20周及孕21～24周血色素(Hb)、红细胞压积(HCT)、血小板计数(PLT)及血小板平均体积(MPV)是否可以对子痫前期起到预测作用。方法选取孕13～24周孕妇共计349例,其中89例子痫前期患者为病例组,260例正常孕妇为对照组,分别于孕13～16周、孕17～20周及孕21～24周采用多样本非参数检验分析方法进行病例对照研究,比较Hb、HCT、PLT及MPV等在3个不同的孕周的差异,寻找孕中期对子痫前期有预测作用的血清学标志物。结果孕13～16周病例组89例,对照组260例,其HCT的差异有统计学意义(P值为0.016,P<0.05),Hb、PLT及MPV之间的差异无统计学意义(P值分别为0.467,0.262,0.073,P>0.05);孕17～20周病例组73例,对照组244例,Hb的差异有统计学意义(P值为0.045,P<0.05),HCT、PLT及MPV之间的差异无统计学意义(P值分别为0.052,0.343,0.193,P>0.05);孕21～24周病例组89例,对照组260例,Hb、HCT及MPV的差异有统计学意义(P值分别为<0.001,0.009,0.019,P<0.05),PLT之间的差异无统计学意义(P值为0.141,P>0.05)。结论孕中期的Hb,HCT,MPV对子痫前期有一定的预测作用;PLT对子痫前期无预测作用。
Objective To discuss whether such markers as the haemoglobin （Hb）, hematocrit （HCT）, platelet count （ PLT）, and mean platelet volume （MPV） of patients at 13 -16 weeks gestation, 17 - 20 weeks gestation, and 21 - 24 weeks gestation can be used to predict preeelampsia. Methods Selected 89 patients with preeclampsia as case group, and 260 normal pregnant women as control group, altogether 349 pregnant women in this study. Useed multi - sample non -parametric test method in case -control study at 13 - 16 weeks gestation, 17 -20 weeks gestation, and 21 -24 weeks gestation. Investigate serological markers for prediction of preeclampsia in the second trimester through comparing the difference of Hb, HCT, PLT and MPV of the two groups in 3 different gestations. Results Investigation of the 89 patients in case group and 260 cases in control group at 13-16 weeks gestation shows that the difference in HCT has statistical significance （ P = 0. 016, P 〈 0.05 ） , while the difference in Hb, PLT and MPV has no statistical signifi- cance （P = 0. 467, 0. 262, 0. 073, P 〉 0. 05 ） ; Investigation of the 73 patients in case group and 244 cases in control group at 17 -20 weeks gestation shows that the difference in Hb has statistical significance （P = 0. 045, P 〈 0. 05 ）, while the difference in HCT, PLT and MPV has no statistical significance （P = 0. 052, 0. 343, 0. 193, P 〉 0.05） ; I vestigation of the 89 patients in case group and 260 cases in control group at 21 - 24 weeks gestation shows that the difference in Hb, HCT and MPV has statistical significance （P 〈 0. 001, 0. 009, 0. 019, P 〈 0. 05）, while the difference in PLT has no statistical significance （P = 0. 141, P 〉 0.05）. Conclusions Hb, HCT and MPV in the second trimester are likely helpful to the prediction of preeclampsia, whereas PLT cannot be used to predict preeclampsia.
出处
《医药论坛杂志》
2012年第9期1-3,6,共4页
Journal of Medical Forum
