摘要
目的:了解腹膜透析患者脂代谢紊乱与微炎症状态的关系。方法:对60例尿毒症患者腹膜透析前、透析1a内血甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、脂蛋白(a)、载脂蛋白A1(apoA1)、载脂蛋白B(apoB)、血浆白蛋白(Alb)及高敏C反应蛋白(hs-CRP)、IL-6进行检测。60例健康体检者为对照。结果:腹膜透析患者透析前TG、脂蛋白(a)、apoB、hs-CRP、IL-6水平高于对照(t=3.776,2.914,2.309,12.378和11.204,P<0.05),HDL-C和Alb水平低于对照(t=3.285,3.960,P<0.05)。透析过程中,随透析时间的延长,患者血TG、TC、LDL-C、脂蛋白(a)及hs-CRP、IL-6水平均逐渐升高(F=18.953,23.084,14.907,3.394,12.841,3.526,P<0.05),HDL-C水平逐渐降低(F=3.227,P<0.05)。腹膜透析患者透析前血清hs-CRP、IL-6水平与TC、LDL-C和apoB呈正相关(r=0.562～0.871,P<0.05),与Alb呈负相关(r=-0.821和-0.784,P<0.05)。结论:腹膜透析患者存在严重的脂质代谢紊乱及炎症状态,两者可能存在相互作用。
Aim：To investigate the serum lipid profiles and microinflammatory state in patients with peritoneal dialysis（PD） and the relationship between them.Methods：Serum lipid and inflammatory factors（hs-CRP and IL-6） levels were determined in 60 patients before and after PD and 60 healthy control.Results：Compared with those in the normal controls,serum TG,LP（a）,apoB,hs-CRP,and IL-6 levels increased（t = 3.776,2.914,2.309,12.378 and 11.204,P 〈 0.05）,while serum HDL-C and Alb levels decreased（t = 3.285,3.960,P 〈 0.05） in PD patients.In the course of PD,serum TG,TC,LDL-C,LP（a）,hs-CRP,and IL-6 levels increased gradually（F = 18.953,23.084,14.907,3.394,12.841,3.526,P 〈 0.05）,while serum HDL-C level decreased（F = 3.227,P 〈 0.05）.Serum hs-CRP and IL-6 levels had positive relationship with TC,LDL-C and apoB levels（r = 0.562 ～ 0.871,P 〈 0.05）,and negative relationship with Alb（r =-0.821,-0.784,P 〈 0.05） in patients before PD.Conclusion：Hyperlipidemia and microinflammatory state are quite common and severe in PD patients,and there may be mutual effect between them.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2012年第4期547-550,共4页
Journal of Zhengzhou University(Medical Sciences)
关键词
腹膜透析
脂质代谢紊乱
微炎症状态
peritoneal dialysis
abnormalities of lipid metabolism
microinflammatory state
