摘要
目的:比较食管癌高、低发区饮用水微量元素含量及遗传毒性。方法:分别选取食管癌高发区的X村(距沙颍河河床2km以内)和低发区的S村(距沙颍河河床在20km以外),每个村庄采集饮用水30份,采用电感耦合等离子体原子发射光谱法测定饮用水中铜、锌、铁、硒、锰、镍和铅等7种微量元素含量;同时采用蚕豆根尖微核实验检测水的遗传毒性。结果:X村水样中铜、铁、镍、铅含量和铜锌比值高于S村,而锌、硒和锰含量低于S村,差异均有统计学意义(P<0.05);X村和S村饮用水的污染程度分别为重度和中度,X村蚕豆根尖微核细胞千分率高于S村(F=27.159,P<0.001)。结论:食管癌不同发病区饮用水中微量元素含量及遗传毒性存在差异,可能是沙颍河流域食管癌发病率高的原因之一。
Aim ：To compare the trace elements in drinking water and genetic toxicity in high and low incidence area of esophageal cancer in Henan province. Methods：Village X with high incidence of esophageal cancer （less than 2 km away from Shaying River bed） and village S with low incidence of esophageal cancer （ more than 20 km away from Shaying River bed） were selected. Thirty drinking water samples were collected in each village. Cu,Zn, Fe, Se, Mn, Ni and Pb were detec- ted by inductively coupled plasma atomic emission spectrometry. At the same time, vicia micronucleus test was used to test the genotoxicity. Results ：The Cu,Fe,Ni and Pb content and Cu/Zn ratio were higher in village X than those in village S （ P 〈 0.05 ）, whereas, the other three elements were lower in village X than village S （P 〈 0.05 ）. The pollution levels of the village X and S were respectively heavy and mediate. The micronucleus rate was lower in village S than that in village X （F = 27. 159 ,P 〈 0. 001 ）. Conclusion ：The trace element content in drinking water and genetic toxicity are different in dif- ferent incidence area of esophageal cancer,which may explain high incidence of esophageal cancer in Shaying River basin.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2012年第4期431-434,共4页
Journal of Zhengzhou University(Medical Sciences)
关键词
食管肿瘤
饮用水
微量元素
遗传毒性
esophageal neoplasm
drinking water
trace element
genetic toxicity
