摘要
用放射配基结合实验的方法测定70例老年、中年高血压患者及53例年龄相当的正常人的外周血淋巴细胞β受体数及反应性,并进行对比研究,同时分析了高血压患者β受体浓度与血流动力学指标间的关系。结果发现:在正常人中不同年龄及性别间β受体数量及反应性无统计学差别;老年高血压组较中年高血压组及老年对照组β受体数量明显降低,但反应性无差别;β受体数与血流动力学参数间无直线相关。结果提示β受体数量减少在老年高血压中可能参与高血压的发病。
By using radioligand binding assay, the maximal binding capacity ( Bmax ) and irritability (KD) of receptors of the peripheral lymphocytes from 53 normotensives and 70 hypertensives aged from 38 to 94 years were measured. In the meanwhile, hemodynamic parameters were determined in a part of patients. It was shown that both Bmax and KD of the receptors of the lymphocytes in normotensive people did not change with aging and sex. However, the elderly hypertensive patients had a significantly lower Bmax than age-matched normal controls and middle-aged hypertensive patients. There were no significant linear correlation between adrenoceptor Bmax and hemodynamic parameters. Conclusion:The decreased density of p-adreno-ceptor may contribute to the pathogenesis of hypertension in the elderly, but It docs not play an important role
出处
《重庆医科大学学报》
CAS
CSCD
1990年第3期186-190,共5页
Journal of Chongqing Medical University
关键词
高血压
受体
淋巴细胞
病理
Elderly hypertension
P-adrenoceptor
Lymphocytes
