摘要
目的应用二维斑点追踪成像技术(2DSTI)评价2型糖尿病(T2DM)早期患者的左心室收缩、舒张功能。方法分别采集45例左室射血分数正常的T2DM患者及33例正常对照者心尖左室长轴、心尖四腔和心尖二腔观的二维灰阶动态图像,应用西门子公司专用分析软件脱机分析,测量左心室各壁(后间隔PS、侧壁LW、后壁PW、前间隔AS、下壁IW及前壁AW)收缩期平均峰值应变、应变率(Ss、SRs)和舒张早期及舒张晚期平均峰值应变率(SRe、SRa),并计算各室壁的SRe/SRa值。结果与正常组对照比较,糖尿病组左室各壁的Ss均减低,其中PS、PW、AW两组值差异有统计学意义(P<0.05);糖尿病组左室LW、PW、AS及IW的SRs较正常组减低,但差异均无统计学意义(P>0.05);糖尿病组左室各壁的SRe值均较正常组减低,且两组PS、LW、PW及AW的值差异有统计学意义(P<0.05);糖尿病组左室6个室壁的SRa均较正常组显著增高(P<0.05～0.01);糖尿病组左室6个室壁的SRe/SRa值均较正常组减低,其中除PS外其余室壁两组的差异均有统计学意义(P<0.01)。结论 2型糖尿病早期患者存在左室长轴功能损害,且舒张功能指标较收缩功能改变更为敏感;超声二维斑点追踪成像技术具有重要的临床应用价值。
Objective To assess left ventricular(LV) systolic and diastolic function in patients with type 2 diabetes mellitus(T2DM) by 2-dimensional speckle tracking imaging(2DSTI).Methods There were 45 cases with T2DM with normal LV ejection fraction in the patients group,while 33 healthy subjects in the control group.The 2-dimensional loop-cine were obtained in apical 4-chamber view,apical 2-chamber view and long axis of left ventricle view.These views were analysed offline by the special software of SIEMENS Company.The mean values of peak systolic strain(Ss),peak systolic strain rate(SRs),peak early diastole strain rate(SRe) and atrial systolic strain rate(SRa) at the six walls of LV [posterior septum(PS),lateral wall(LW),posterior wall(PW),anterior septum(AS),inferior wall(IW),anterior wall(AW)] were assessed,as well as the ratio of SRe/SRa.Results Compared with the controls,Ss of all walls of T2DM were reduced and the significant differences existed in the values of PS,PW,AW between the two groups(P<0.05).The values of SRs of LW 、PW、 AS and IW in T2DM were reduced,but there were no significant differences between the two groups(P>0.05).SRe of all walls in T2DM were reduced and the values of PS,LW,PW,AW of the two groups displayed significant differences(P<0.05).SRa of all walls in T2DM were significantly increased(P<0.05).SRe/SRa of all walls in T2DM were reduced and the values between the two groups displayed significant differences except PS(P<0.01).Conclusion The LV longitude function was suffered in early patients with T2DM,and there is higher sensitivity in the changes of diastolic function than systolic function.
出处
《医学研究杂志》
2012年第8期60-64,共5页
Journal of Medical Research
基金
浙江省中医药科学研究基金资助项目(2010ZB096)
