摘要
microRNA是机体内源性表达的长度为18～25个核苷酸的非编码单链小分子RNA通过完全或不完全互补的方式与靶基因结合并使其mRNA裂解或抑制其蛋白翻译,进而在转录后水平调控靶基因的表达,已经作为基因表达的强力调控因子成为肿瘤领域的研究热点近年来,miR-200家族在上皮来源恶性肿瘤中的表达和功能研究逐渐成为焦点,如研究其在肿瘤细胞增殖、侵袭转移等方面的作用机制和靶点miRNA-200b是miRNA-200家族具有代表性的一员,本文对miRNA-200b结构特点。
MicroRNAs （miRNAs） are small endogenous regulatory RNAs composed of approximately 18 nucleotides to 25 nucleotides, and are highly conserved non-coding RNAs, which regulate gene expression in post-transcriptional processing through complete or incomplete combination with the target genes. A strong regulatory factor, miRNA has become a hotspot in tumor research. In recent years, the miRNA-200 family has played important roles in the expression and function of tumors of epithelial origin. For example, the mechanism and targets in tumor cell proliferation, invasion, and metastasis have been investigated. The miRNA-200b is a member of miRNA-200 family. In this article, the latest advances in structural features and mechanism of miRNA-200b and the relationship between miRNA-200b and tumors of epithelial origin were reviewed.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2012年第17期1329-1331,共3页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金(编号:81172333)资助~~
